Kallikrein 8 antibody (AA 51-150)

Catalog No. ABIN759116

Product Details anti-Kallikrein 8 Antibody

Target: Kallikrein 8 (KLK8)

Binding Specificity: AA 51-150

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Kallikrein 8 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse KLK8

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Kallikrein 8 antibody (ABIN759116)

Hadamitzky, Herring, Kirchhof, Bendix, Haight, Keyvani, Lückemann, Unteroberdörster, Schedlowski: "Repeated Systemic Treatment with Rapamycin Affects Behavior and Amygdala Protein Expression in Rats." in: The international journal of neuropsychopharmacology, Vol. 21, Issue 6, pp. 592-602, (2019) (PubMed).

Target Details for Kallikrein 8

Target: Kallikrein 8 (KLK8)

Alternative Name: KLK8 (KLK8 Products)

Synonyms: HNP antibody, NP antibody, NRPN antibody, PRSS19 antibody, TADG14 antibody, bsp1 antibody, KLK8 antibody, BSP1 antibody, Nrpn antibody, Prss19 antibody, kallikrein related peptidase 8 antibody, kallikrein related-peptidase 8 antibody, KLK8 antibody, Klk8 antibody

Background:

Synonyms: BSP1, Nrpn, Prss19, Kallikrein-8, mK8, Neuropsin, NP, Serine protease 19, Klk8

Background: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.

Gene ID: 259277

UniProt: Q61955

Pathways: Complement System