CASC3 antibody (pTyr181) (Biotin)

Catalog No. ABIN757554

Product Details anti-CASC3 Antibody (Biotin)

Target: CASC3 (Cancer Susceptibility Candidate 3 (CASC3))

Binding Specificity: pTyr181

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CASC3 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human CASC3 around the phosphorylation site of Tyr181

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CASC3

Target: CASC3 (Cancer Susceptibility Candidate 3 (CASC3))

Alternative Name: CASC3 (CASC3 Products)

Synonyms: BTZ antibody, MLN51 antibody, Btz antibody, Mln51 antibody, CASC3 antibody, btz antibody, mln51 antibody, StMLN51 antibody, barentsz antibody, XlMLN51 antibody, cancer susceptibility 3 antibody, cancer susceptibility candidate 3 antibody, protein CASC3 antibody, cancer susceptibility 3 S homeolog antibody, CASC3 antibody, Casc3 antibody, casc3 antibody, casc3.S antibody

Background:

Synonyms: Barentsz protein, Btz, Cancer susceptibility candidate gene 3 protein, Metastatic lymph node protein 51, MLN 51 protein, MLN51, Protein barentsz, Protein CASC3, Protein MLN 51, CASC3_HUMAN.

Background: The multiprotein exon junction complex (EJC) is deposited on mRNAs upstream of exonexon junctions as a consequence of pre-mRNA splicing. In mammalian cells, this complex serves as a key modulator of spliced mRNA metabolism. MLN51 is a nucleocytoplasmic shuttling protein that is overexpressed in breast cancer. The function of MLN51 in mammals remains elusive. Its fly homolog, named barentsz, as well as the proteins mago nashi and tsunagi have been shown to be required for proper oskar mRNA localization to the posterior pole of the oocyte. Magoh and Y14, the human homologs of mago nashi and tsunagi, are core components of the exon junction complex (EJC). The EJC is assembled on spliced mRNAs and plays important roles in post-splicing events including mRNA export, nonsense-mediated mRNA decay, and translation. Human MLN51 is an RNA-binding protein present in ribonucleo-protein complexes.

Gene ID: 22794