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CASC3 antibody (pTyr181)

CASC3 Reactivity: Mouse WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN757552
  • Target See all CASC3 Antibodies
    CASC3 (Cancer Susceptibility Candidate 3 (CASC3))
    Binding Specificity
    • 15
    • 14
    • 9
    • 9
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    pTyr181
    Reactivity
    • 46
    • 36
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Mouse
    Host
    • 74
    • 1
    Rabbit
    Clonality
    • 75
    Polyclonal
    Conjugate
    • 25
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CASC3 antibody is un-conjugated
    Application
    • 65
    • 28
    • 26
    • 26
    • 25
    • 14
    • 5
    • 4
    • 4
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Mouse
    Predicted Reactivity
    Human,Rat,Cow,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human CASC3 around the phosphorylation site of Tyr181
    Isotype
    IgG
    Top Product
    Discover our top product CASC3 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    CASC3 (Cancer Susceptibility Candidate 3 (CASC3))
    Alternative Name
    CASC3 (CASC3 Products)
    Synonyms
    BTZ antibody, MLN51 antibody, Btz antibody, Mln51 antibody, CASC3 antibody, btz antibody, mln51 antibody, StMLN51 antibody, barentsz antibody, XlMLN51 antibody, cancer susceptibility 3 antibody, cancer susceptibility candidate 3 antibody, protein CASC3 antibody, cancer susceptibility 3 S homeolog antibody, CASC3 antibody, Casc3 antibody, casc3 antibody, casc3.S antibody
    Background

    Synonyms: Barentsz protein, Btz, Cancer susceptibility candidate gene 3 protein, Metastatic lymph node protein 51, MLN 51 protein, MLN51, Protein barentsz, Protein CASC3, Protein MLN 51, CASC3_HUMAN.

    Background: The multiprotein exon junction complex (EJC) is deposited on mRNAs upstream of exonexon junctions as a consequence of pre-mRNA splicing. In mammalian cells, this complex serves as a key modulator of spliced mRNA metabolism. MLN51 is a nucleocytoplasmic shuttling protein that is overexpressed in breast cancer. The function of MLN51 in mammals remains elusive. Its fly homolog, named barentsz, as well as the proteins mago nashi and tsunagi have been shown to be required for proper oskar mRNA localization to the posterior pole of the oocyte. Magoh and Y14, the human homologs of mago nashi and tsunagi, are core components of the exon junction complex (EJC). The EJC is assembled on spliced mRNAs and plays important roles in post-splicing events including mRNA export, nonsense-mediated mRNA decay, and translation. Human MLN51 is an RNA-binding protein present in ribonucleo-protein complexes.

    Gene ID
    22794
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