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NCEH1 antibody (AA 151-250)

NCEH1 Reactivity: Human ELISA, IF (cc), IF (p), IHC (fro), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN755752
  • Target See all NCEH1 Antibodies
    NCEH1 (Neutral Cholesterol Ester Hydrolase 1 (NCEH1))
    Binding Specificity
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 151-250
    Reactivity
    • 21
    • 13
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 20
    • 1
    Rabbit
    Clonality
    • 21
    Polyclonal
    Conjugate
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NCEH1 antibody is un-conjugated
    Application
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    Human,Mouse,Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human AADACL1
    Isotype
    IgG
    Top Product
    Discover our top product NCEH1 Primary Antibody
  • Application Notes
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    NCEH1 (Neutral Cholesterol Ester Hydrolase 1 (NCEH1))
    Alternative Name
    AADACL1 (NCEH1 Products)
    Synonyms
    AADACL1 antibody, NCEH antibody, Aadacl1 antibody, B230106I24Rik antibody, CPO-BP antibody, Nceh antibody, RGD1311104 antibody, nceh antibody, aadacl1 antibody, MGC79479 antibody, nceh1b antibody, zgc:153038 antibody, zgc:92416 antibody, neutral cholesterol ester hydrolase 1 antibody, neutral cholesterol ester hydrolase 1 S homeolog antibody, neutral cholesterol ester hydrolase 1b, tandem duplicate 1 antibody, neutral cholesterol ester hydrolase 1a antibody, NCEH1 antibody, Nceh1 antibody, nceh1 antibody, nceh1.S antibody, nceh1b.1 antibody, nceh1a antibody
    Background

    Synonyms: Arylacetamide deacetylase like 1, Arylacetamide deacetylase-like 1, Kiaa1363, NCEH, Nceh1, NCEH1_HUMAN, Neutral cholesterol ester hydrolase 1, Neutral cholesterol ester hydrolase.

    Background: The assembly of very-low-density lipoproteins (VLDLs) in the secretory apparatus of the hepatocyte relies on the mobilization of triacylglycerol (TAG) from the cytosolic pool by lipolysis and re-esterification. However, some of the re-esterified TAG products are returned to the cytosolic pool in the liver, which protects vulnerable body tissues from excess lipotoxic non-esterified fatty acids in the plasma. Some of the lipases involved in this process include arylacetamide deacetylase (AADAC) and its related proteins AADACL1 and AADACL2. AADAC, a single pass type II membrane protein of the endoplasmic reticulum, is expressed in hepatocytes, intestinal mucosal cells, pancreas and adrenal gland. It plays an important role in the metabolic activation of arylamine substrates to ultimate carcinogens. AADACL1 hydrolyzes the metabolic intermediate 2-acetyl monoalkylglycerol, and its inactivation results in disruption of ether lipid metabolism in cancer cells and impaired cell migration and tumor growth.

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