proBNP antibody (AA 21-121)

Catalog No. ABIN755512

Product Details anti-proBNP Antibody

Target: proBNP (Pro-Brain Natriuretic Peptide (proBNP))

Binding Specificity: AA 21-121

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This proBNP antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse proBNP

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for proBNP

Target: proBNP (Pro-Brain Natriuretic Peptide (proBNP))

Alternative Name: proBNP (proBNP Products)

Synonyms: BNP antibody, natriuretic peptide B antibody, NPPB antibody

Background:

Synonyms: BNP 32, BNP1-28, BNP1-29, BNP1-30, BNP1-32, BNP2-31, BNP3-29, BNP3-30, BNP3-32, BNP4-27, BNP4-29, BNP4-30, BNP4-31, BNP4-32, BNP5-29, BNP5-31, BNP5-32, Brain natriuretic peptide 32, Brain type natriuretic peptide, Gamma brain natriuretic peptide, Natriuretic peptide B, Natriuretic peptide brain type, Natriuretic peptide precursor B, natriuretic peptide, brain type, ANFB_MOUSE, Natriuretic peptides B, natriuretic protein, NPPB, NPPB protein.

Background: This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.

Gene ID: 18158