RRM2B antibody (AA 131-230)

Catalog No. ABIN755023

Product Details anti-RRM2B Antibody

Target: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Binding Specificity: AA 131-230

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRM2B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human p53R2/RRM2B

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for RRM2B

Target: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Alternative Name: p53R2 (RRM2B Products)

Synonyms: p53r2 antibody, RRM2B antibody, MTDPS8A antibody, MTDPS8B antibody, P53R2 antibody, p53R2 antibody, ribonucleotide reductase M2 B (TP53 inducible) S homeolog antibody, ribonucleotide reductase regulatory TP53 inducible subunit M2B antibody, ribonucleotide reductase M2 B (TP53 inducible) antibody, rrm2b.S antibody, RRM2B antibody, rrm2b antibody, Rrm2b antibody

Background:

Synonyms: DKFZp686M05248, MGC102856, MGC42116, MTDPS8A, MTDPS8B, p53 inducible ribonucleotide reductase small subunit 2 homolog, p53 inducible ribonucleotide reductase small subunit 2 like protein, p53 R2, p53-inducible ribonucleotide reductase small subunit 2-like protein, p53R2, Ribonucleoside diphosphate reductase M2 subunit B, Ribonucleoside-diphosphate reductase subunit M2 B, Ribonucleotide reductase M2 B TP53 inducible, Ribonucleotide reductase M2 B, Ribonucleotide reductase small subunit like 2 p53 inducible, RIR2B_HUMAN, RRM 2B, RRM2B, TP53 inducible ribonucleotide reductase M2 B, TP53-inducible ribonucleotide reductase M2 B.

Background: This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010].

Gene ID: 50484

Pathways: p53 Signaling, Negative Regulation of intrinsic apoptotic Signaling