SOX9 antibody (AA 121-220)

Catalog No. ABIN754963

Product Details anti-SOX9 Antibody

Target: SOX9 (SRY (Sex Determining Region Y)-Box 9 (SOX9))

Binding Specificity: AA 121-220

Reactivity: Human, Mouse, Rat, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOX9 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rabbit, Rat

Predicted Reactivity: Dog,Cow,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SOX9

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-SOX9 antibody (ABIN754963)

Webster, Cooley-Themm, Barnett, Bach, Vainner, Webster, Linn: "Evidence of BrdU-positive retinal neurons after application of an Alpha7 nicotinic acetylcholine receptor agonist." in: Neuroscience, Vol. 346, pp. 437-446, (2017) (PubMed).

Montorsi, Guizzetti, Alecci, Caporali, Martello, Atene, Parenti, Pizzini, Zanovello, Bortoluzzi, Ferrari, Grande, Zanocco-Marani: "Loss of zfp36 expression in colorectal cancer correlates to wnt/ ß-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of zeb1, sox9 and macc1." in: Oncotarget, Vol. 7, Issue 37, pp. 59144-59157, (2016) (PubMed).

Yang, Lu, Guo: "Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis." in: Molecular medicine reports, Vol. 14, Issue 5, pp. 4075-4082, (2016) (PubMed).

Chang, Lin, Lin, Wang, Hsu, Yeh: "The repair of full-thickness articular cartilage defect using intra-articular administration of N-acetyl-D-glucosamine in the rabbit knee: randomized controlled trial." in: Biomedical engineering online, Vol. 14, pp. 105, (2016) (PubMed).

Wu, Zhu, Sun, Hu: "Subchondral bone changes and chondrogenic capacity of progenitor cells from subchondral bone in the collagenase-induced temporomandibular joints osteoarthritis rabbit model." in: International journal of clinical and experimental pathology, Vol. 8, Issue 9, pp. 9782-9, (2016) (PubMed).

Wang, Ju, Sun, Hou, Yang, Zhang: "Overexpression of heparan sulfate 6-O-sulfotransferase-2 enhances fibroblast growth factor-mediated chondrocyte growth and differentiation." in: International journal of molecular medicine, Vol. 36, Issue 3, pp. 825-32, (2015) (PubMed).

Papaioannou, Mirzamohammadi, Lisse, Nishimori, Wein, Kobayashi: "MicroRNA-140 provides robustness to the regulation of hypertrophic chondrocyte differentiation by the PTHrP-HDAC4 pathway." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, (2014) (PubMed).

Mi, Chen, Wu, Wang, Gao: "Study of the effect of miR‑124 and the SOX9 target gene in Hirschsprung's disease." in: Molecular medicine reports, Vol. 9, Issue 5, pp. 1839-43, (2014) (PubMed).

Target Details for SOX9

Target: SOX9 (SRY (Sex Determining Region Y)-Box 9 (SOX9))

Alternative Name: SOX9 (SOX9 Products)

Synonyms: CMD1 antibody, CMPD1 antibody, SRA1 antibody, LOC100227849 antibody, 2010306G03Rik antibody, AV220920 antibody, mKIAA4243 antibody, SOX-9 antibody, cmd1 antibody, cmpd1 antibody, sox-9 antibody, sox9 antibody, sox9-a antibody, sox9-b antibody, sox9b antibody, sra1 antibody, SRY-box 9 antibody, transcription factor SOX-9 antibody, SRY (sex determining region Y)-box 9 antibody, SRY box 9 antibody, SRY-box 9 L homeolog antibody, SOX9 antibody, LOC100227849 antibody, Sox9 antibody, sox9.L antibody

Background:

Synonyms: CMD1, SRA1, CMPD1, Transcription factor SOX-9, SOX9

Background: Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.

Gene ID: 6662

UniProt: P48436

Pathways: EGFR Signaling Pathway, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development