HMGCR antibody (pSer872)

Catalog No. ABIN753283

Product Details anti-HMGCR Antibody

Target: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Binding Specificity: pSer872

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMGCR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This phosphorylation site is homologous to that of Ser871 in Mouse and Rat.

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human HMGCR around the phosphorylation site of Ser872

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-HMGCR antibody (ABIN753283)

Zanoni, Aiello, Arnoldi, Lammi: "Hempseed Peptides Exert Hypocholesterolemic Effects with a Statin-Like Mechanism." in: Journal of agricultural and food chemistry, Vol. 65, Issue 40, pp. 8829-8838, (2017) (PubMed).

Yang, Ouyang, Chen, Pang, Dong, Yang, Liu, Peng, Wang, Zhang, Ren: "HMG-CoA reductase is negatively associated with PCV2 infection and PCV2-induced apoptotic cell death." in: The Journal of general virology, Vol. 95, Issue Pt 6, pp. 1330-7, (2014) (PubMed).

Target Details for HMGCR

Target: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Alternative Name: HMGCR (HMGCR Products)

Synonyms: HMGR antibody, LDLCQ3 antibody, hmg-coa-r antibody, HMG-CoAR antibody, Red antibody, 3H3M antibody, BcDNA:LD15354 antibody, CG10367 antibody, Clb antibody, DmHMG-CoAr antibody, Dmel\\CG10367 antibody, HMGCR antibody, HMGCR_Dm antibody, HMGCoAR antibody, HMGCoARr antibody, HMGCoAr antibody, HmG-CoAR antibody, Hmg antibody, bro1 antibody, bs32f05.y1 antibody, clb antibody, hmgc antibody, hmgcr antibody, hmgrc antibody, l(3)01152 antibody, l(3)04684 antibody, hmgcr2 antibody, im:6912716 antibody, zgc:110746 antibody, 3-hydroxy-3-methylglutaryl-CoA reductase antibody, 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog antibody, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase antibody, HMG Coenzyme A reductase antibody, 3-hydroxy-3-methylglutaryl-CoA reductase b antibody, HMGCR antibody, hmgcr.L antibody, Hmgcr antibody, hmgcrb antibody

Background:

Synonyms: LDLCQ3, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase, HMGCR, phospho HMGCR, p-HMGCR

Background: Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Gene ID: 3156

UniProt: P04035

Pathways: AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha