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TLR6 antibody (AA 301-400)

TLR6 Reactivity: Human, Mouse, Rat WB, ELISA, FACS, IHC (p), IHC (fro), IF (cc), IF (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN749573
  • Target See all TLR6 Antibodies
    TLR6 (Toll-Like Receptor 6 (TLR6))
    Binding Specificity
    • 8
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 301-400
    Reactivity
    • 61
    • 20
    • 3
    • 3
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 45
    • 18
    • 1
    Rabbit
    Clonality
    • 45
    • 19
    Polyclonal
    Conjugate
    • 37
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TLR6 antibody is un-conjugated
    Application
    • 36
    • 34
    • 26
    • 21
    • 8
    • 7
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Mouse, Rat
    Predicted Reactivity
    Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TLR6
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Shmuel-Galia, Aychek, Fink, Porat, Zarmi, Bernshtein, Brenner, Jung, Shai: "Neutralization of pro-inflammatory monocytes by targeting TLR2 dimerization ameliorates colitis." in: The EMBO journal, Vol. 35, Issue 6, pp. 685-98, (2016) (PubMed).

  • Target
    TLR6 (Toll-Like Receptor 6 (TLR6))
    Alternative Name
    TLR6 (TLR6 Products)
    Synonyms
    TLR1 antibody, TLR16 antibody, CD286 antibody, TLR-6 antibody, toll-like receptor 1 family member A antibody, toll like receptor 6 antibody, toll-like receptor 6 antibody, TLR1A antibody, TLR6 antibody, Tlr6 antibody
    Background

    Synonyms: CD286, Toll-like receptor 6, TLR6

    Background: Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

    Gene ID
    10333
    UniProt
    Q9Y2C9
    Pathways
    TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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