NFAM1 antibody (AA 81-180)

Catalog No. ABIN749033

Product Details anti-NFAM1 Antibody

Target: NFAM1 (NFAT Activating Protein with ITAM Motif 1 (NFAM1))

Binding Specificity: AA 81-180

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFAM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NFAM1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-NFAM1 antibody (ABIN749033)

Sambandam, Sundaram, Saigusa, Balasubramanian, Reddy: "NFAM1 signaling enhances osteoclast formation and bone resorption activity in Paget's disease of bone." in: Bone, Vol. 101, pp. 236-244, (2018) (PubMed).

Target Details for NFAM1

Target: NFAM1 (NFAT Activating Protein with ITAM Motif 1 (NFAM1))

Alternative Name: NFAM1 (NFAM1 Products)

Synonyms: 4921501M20Rik antibody, Cnaip antibody, CNAIP antibody, bK126B4.4 antibody, RGD1308316 antibody, NFAT activating protein with ITAM motif 1 antibody, Nfat activating molecule with ITAM motif 1 antibody, NFAM1 antibody, Nfam1 antibody

Background:

Synonyms: CNAIP, bK126B4.4, NFAT activation molecule 1, Calcineurin/NFAT-activating ITAM-containing protein, NFAT-activating protein with ITAM motif 1, NFAM1

Background: May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.

Gene ID: 150372

UniProt: Q8NET5