C5b-9 antibody

Catalog No. ABIN748913

Product Details anti-C5b-9 Antibody

Target: C5b-9 (Terminal Complement Complex C5b-9 (C5b-9))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C5b-9 antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Purified Human SC5b-9 Complex

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-C5b-9 antibody (ABIN748913)

Üçal, Haindl, Adzemovic, Strasser, Theisl, Zeitelhofer, Kraitsy, Ropele, Schäfer, Fazekas, Hochmeister: "Widespread cortical demyelination of both hemispheres can be induced by injection of pro-inflammatory cytokines via an implanted catheter in the cortex of MOG-immunized rats." in: Experimental neurology, Vol. 294, pp. 32-44, (2017) (PubMed).

Adzemovic, Zeitelhofer, Hochmeister, Gustafsson, Jagodic: "Efficacy of vitamin D in treating multiple sclerosis-like neuroinflammation depends on developmental stage." in: Experimental neurology, Vol. 249, pp. 39-48, (2013) (PubMed).

Target Details for C5b-9

Target: C5b-9 (Terminal Complement Complex C5b-9 (C5b-9))

Abstract: C5b-9 Products

Background:

Synonyms: C9D, ARMD15, Complement component C9, C9

Background: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.

Gene ID: 735

UniProt: P02748