IL15RA antibody (AA 51-150) (Biotin)

Catalog No. ABIN747895

Product Details anti-IL15RA Antibody (Biotin)

Target: IL15RA (Interleukin 15 Receptor, alpha (IL15RA))

Binding Specificity: AA 51-150

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL15RA antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IL-15RA

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for IL15RA

Target: IL15RA (Interleukin 15 Receptor, alpha (IL15RA))

Alternative Name: IL-15RA (IL15RA Products)

Synonyms: IL15RA antibody, CD215 antibody, AA690181 antibody, IL-15RA antibody, interleukin 15 receptor subunit alpha antibody, interleukin 15 receptor, alpha chain antibody, IL15RA antibody, Il15ra antibody

Background:

Synonyms: Interleukin-15 receptor subunit alpha, IL 15R alpha, IL15RA, Interleukin 15 receptor alpha, Interleukin 15 receptor subunit alpha, Soluble interleukin 15 receptor subunit alpha, I15RA_HUMAN.

Background: IL15RA is a cytokine receptor that specifically binds IL15 with high affinity. It shares two subunits with the receptor of IL2, the IL2R beta and IL2R gamma chains. This forms the basis of many overlapping biological activities of IL15 and IL2. The IL2 receptor requires an additional IL2-specific alpha subunit for high affinity IL2 binding. This protein is structurally related to IL2R alpha, but is capable of binding IL15 with high affinity independent of other subunits, which suggests the distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. There are nine different isoforms.

Gene ID: 3601

Pathways: JAK-STAT Signaling