IL10RB antibody (AA 21-120)

Catalog No. ABIN747848

Product Details anti-IL10RB Antibody

Target: IL10RB (Interleukin 10 Receptor, beta (IL10RB))

Binding Specificity: AA 21-120

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL10RB antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IL10RB

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-IL10RB antibody (ABIN747848)

Lopušná, Benkóczka, Lupták, Matúšková, Lukáčiková, Ovečková, Režuchová: "Murine gammaherpesvirus targets type I IFN receptor but not type III IFN receptor early in infection." in: Cytokine, Vol. 83, pp. 158-70, (2016) (PubMed).

Ohnuma, Hatano, Aune, Otsuka, Iwata, Dang, Yamada, Morimoto: "Regulation of pulmonary graft-versus-host disease by IL-26+CD26+CD4 T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 8, pp. 3697-712, (2015) (PubMed).

Target Details for IL10RB

Target: IL10RB (Interleukin 10 Receptor, beta (IL10RB))

Alternative Name: IL10RB (IL10RB Products)

Synonyms: IL10R2 antibody, IL10RB antibody, il10r2 antibody, CDW210B antibody, CRF2-4 antibody, CRFB4 antibody, D21S58 antibody, D21S66 antibody, IL-10R2 antibody, 6620401D04Rik antibody, AI528744 antibody, Crfb4 antibody, D16H21S58 antibody, D21S58h antibody, Il10r2 antibody, RGD1560373 antibody, interleukin 10 receptor subunit beta antibody, interleukin 10 receptor subunit beta S homeolog antibody, interleukin-10 receptor subunit beta antibody, interleukin 10 receptor, beta antibody, IL10RB antibody, il10rb.S antibody, LOC473966 antibody, LOC478404 antibody, il10rb antibody, Il10rb antibody

Background:

Synonyms: Interleukin-10 receptor subunit beta, IL-10 receptor subunit beta, IL-10R subunit beta, IL-10RB, Cytokine receptor class-II member 4, Cytokine receptor family 2 member 4, CRF2-4, Interleukin-10 receptor subunit 2, IL-10R subunit 2, IL-10R2, CDw210b, IL10RB, CRFB4, D21S58, D21S66

Background: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.

Gene ID: 3588

UniProt: Q08334