TYK2 antibody (pTyr1054, pTyr1055)

Catalog No. ABIN746318

Product Details anti-TYK2 Antibody

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Binding Specificity: pTyr1054, pTyr1055

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Tyk2 around the phosphorylation site of Tyr1054/1055

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TYK2

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Alternative Name: Tyk2 + (TYK2 Products)

Synonyms: JTK1 antibody, tyrosine kinase 2 antibody, TYK2 antibody, Tyk2 antibody

Background:

Synonyms: TYK2Tyr1054/1055, Tyk2phospho Y1054/1055, TYK2 phospho Tyr1054/1055, p-TYK2 Tyr1054/1055, JTK 1, JTK1, TYK 2, Non receptor tyrosine protein kinase 2, Non receptor tyrosine protein kinase TYK2, Protein Tyrosine Kinase 2, Tyrosine kinase 2, TYK2_HUMAN, Non-receptor tyrosine-protein kinase TYK2.

Background: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq].

Gene ID: 7297

Pathways: JAK-STAT Signaling, Hepatitis C