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CD163 antibody (AA 1001-1121)

CD163 Reactivity: Human, Mouse, Rat, Pig, Dog WB, FACS, ELISA, IHC (p), IHC (fro), ICC, IF (cc), IF (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN741570
  • Target See all CD163 Antibodies
    CD163
    Binding Specificity
    • 16
    • 15
    • 15
    • 10
    • 8
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1001-1121
    Reactivity
    • 128
    • 47
    • 28
    • 27
    • 18
    • 5
    • 3
    • 1
    Human, Mouse, Rat, Pig, Dog
    Host
    • 108
    • 45
    • 1
    Rabbit
    Clonality
    • 95
    • 58
    • 1
    Polyclonal
    Conjugate
    • 51
    • 18
    • 12
    • 8
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD163 antibody is un-conjugated
    Application
    • 107
    • 70
    • 50
    • 38
    • 26
    • 25
    • 25
    • 24
    • 21
    • 20
    • 14
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Dog, Human, Mouse, Pig, Rat
    Predicted Reactivity
    Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CD163/M130
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Riuzzi, Beccafico, Sagheddu, Chiappalupi, Giambanco, Bereshchenko, Riccardi, Sorci, Donato: "Levels of S100B protein drive the reparative process in acute muscle injury and muscular dystrophy." in: Scientific reports, Vol. 7, Issue 1, pp. 12537, (2019) (PubMed).

    Kobori, Hamasaki, Kitaura, Yamazaki, Nishinaka, Niwa, Nakao, Wake, Mori, Yoshino, Nishibori, Takahashi: "Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis." in: Frontiers in immunology, Vol. 9, pp. 334, (2019) (PubMed).

    Yin, Chang, Xu: "Expressions Profiles of the Proteins Associated with Carbohydrate Metabolism in Rat Liver Regeneration." in: BioMed research international, Vol. 2017, pp. 8428926, (2018) (PubMed).

    Chen, Zhang, Wang, Chen, Yan, Zhang, Zhang: "Peptide-modified chitosan hydrogels promote skin wound healing by enhancing wound angiogenesis and inhibiting inflammation." in: American journal of translational research, Vol. 9, Issue 5, pp. 2352-2362, (2017) (PubMed).

    Bobi, Solanes, Fernández-Jiménez, Galán-Arriola, Dantas, Fernández-Friera, Gálvez-Montón, Rigol-Monzó, Agüero, Ramírez, Roqué, Bayés-Genís, Sánchez-González, García-Álvarez, Sabaté, Roura, Ibáñez et al.: "Intracoronary Administration of Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells Improves Myocardial Perfusion But Not Left Ventricle Function, in a Translational Model of Acute Myocardial ..." in: Journal of the American Heart Association, Vol. 6, Issue 5, (2017) (PubMed).

    Gerzanich, Makar, Guda, Kwon, Stokum, Woo, Ivanova, Ivanov, Mehta, Morris, Bryan, Bever, Simard: "Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis." in: Journal of neuroinflammation, Vol. 14, Issue 1, pp. 177, (2017) (PubMed).

    Lee, Liao, Wang, Yang, Luo, Varki, Qiu, Ren, Fu, Feng: "Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions." in: Cell reports, Vol. 21, Issue 7, pp. 1870-1882, (2017) (PubMed).

    Dinulovic, Furrer, Di Fulvio, Ferry, Beer, Handschin: "PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle." in: Skeletal muscle, Vol. 6, pp. 38, (2017) (PubMed).

    Tauchi, Tanaka, Kumamoto, Tokumoto, Sakimura, Sakurai, Kimura, Toyokawa, Amano, Kubo, Muguruma, Yashiro, Maeda, Ohira, Hirakawa: "Tumor-associated macrophages induce capillary morphogenesis of lymphatic endothelial cells derived from human gastric cancer." in: Cancer science, Vol. 107, Issue 8, pp. 1101-9, (2017) (PubMed).

    Jacobsen, Mentzel, Olesen, Huby, Jørgensen, Barrès, Fredholm, Simar: "Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity." in: Journal of diabetes research, Vol. 2016, pp. 8539057, (2016) (PubMed).

    Kugo, Zaima, Tanaka, Mouri, Yanagimoto, Hayamizu, Hashimoto, Sasaki, Sano, Yata, Urano, Setou, Unno, Moriyama: "Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm." in: Scientific reports, Vol. 6, pp. 31268, (2016) (PubMed).

    Drel, Tan, Barnes, Gorin, Lee, Wagner: "Centrality of bone marrow in the severity of gadolinium-based contrast-induced systemic fibrosis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 30, Issue 9, pp. 3026-38, (2016) (PubMed).

    Das, Singh, Majid, Sherman, Mukhopadhyay, Wright, Martin, Dunn, Baker: "Syndesome Therapeutics for Enhancing Diabetic Wound Healing." in: Advanced healthcare materials, Vol. 5, Issue 17, pp. 2248-60, (2016) (PubMed).

    Chen, Shi, Zhang, Chen, Wang, Zhang, Tian, Yan, Li, Zhong, Xing, Zhang, Zhang: "Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing." in: Scientific reports, Vol. 5, pp. 18104, (2016) (PubMed).

    Fernandez-Bustamante, Agazio, Wilson, Elkins, Domaleski, He, Baer, Moss, Wischmeyer, Repine et al.: "Brief Glutamine Pretreatment Increases Alveolar Macrophage CD163/Heme Oxygenase-1/p38-MAPK Dephosphorylation Pathway and Decreases Capillary Damage but Not Neutrophil Recruitment in ..." in: PLoS ONE, Vol. 10, Issue 7, pp. e0130764, (2016) (PubMed).

    Tepeköylü, Lobenwein, Blunder, Kozaryn, Dietl, Ritschl, Pechriggl, Blumer, Bitsche, Schistek, Kotsch, Fritsch, Grimm, Holfeld: "Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice†." in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Vol. 47, Issue 3, pp. e80-90, (2015) (PubMed).

    Ge, Li, Jiang, You, Liu, Zhong, Huang, Xing: "Integration of nondegradable polystyrene and degradable gelatin in a core-sheath nanofibrous patch for pelvic reconstruction." in: International journal of nanomedicine, Vol. 10, pp. 3193-201, (2015) (PubMed).

    Franken, Klein, Spasova, Elsukova, Wiedwald, Welz, Knolle, Farle, Limmer, Kurts: "Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates." in: Scientific reports, Vol. 5, pp. 12940, (2015) (PubMed).

  • Target
    CD163
    Alternative Name
    Cd163/M130 (CD163 Products)
    Synonyms
    DMBT1 antibody, CD163 antibody, CD163v2 antibody, CD163v3 antibody, M130 antibody, MM130 antibody, deleted in malignant brain tumors 1 protein-like antibody, CD163 molecule antibody, CD163 antigen antibody, LOC426820 antibody, CD163 antibody, Cd163 antibody
    Background

    Synonyms: M13, MM13, Scavenger receptor cysteine-rich type 1 protein M13, Hemoglobin scavenger receptor, CD163, M130

    Background: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

    Gene ID
    9332
    UniProt
    Q86VB7
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