CD11b antibody (AA 520-570)

Catalog No. ABIN741285

Product Details anti-CD11b Antibody

Key Features:

• High quality CD11b Primary Antibody for the detection of ITGAM.
• Reliable product with high standard validation data

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Binding Specificity: AA 520-570

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD11b antibody is un-conjugated

Application: Flow Cytometry (FACS)

Cross-Reactivity: Human, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CD11c

Isotype: IgG

Product Specific Information:

What can the CD11b Antibody ABIN741285 be used for?: This polyclonal CD11b Antibody detects CD11b. The CD11b Antibody has been validated for various applications and can be used for the detection of CD11b and derivatives by Flow Cytometry.

What validation data is available for this CD11b Antibody?: The primary antibody is referenced in 4 publications and is characterized by a proven, very high reliability. It has currently 7 product images that show its performance in a variety of applications. The product is currently available in 100 μL quantity. CD11b Antibody for the detection of CD11b and derivatives.

What is the function of CD11b?: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

Application Details

Application Notes: WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

References for anti-CD11b antibody (ABIN741285)

Ju, Xing, Yang, Zheng, Jia, Zhang, Ren: "An effective cytokine adjuvant vaccine induces autologous T-cell response against colon cancer in an animal model." in: BMC immunology, Vol. 17, Issue 1, pp. 31, (2016) (PubMed).

Zhang, Wu, Hayashi, Okada, Nakanishi: "Peripheral role of cathepsin S in Th1 cell-dependent transition of nerve injury-induced acute pain to a chronic pain state." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 8, pp. 3013-22, (2014) (PubMed).

Di Filippo, Rossi, Ferraro, Maisto, De Angelis, Ferraraccio, Rotondo, DAmico: "Involvement of proteasome and macrophages M2 in the protection afforded by telmisartan against the acute myocardial infarction in Zucker diabetic fatty rats with metabolic syndrome." in: Mediators of inflammation, Vol. 2014, pp. 972761, (2014) (PubMed).

Ahn, Ruiz, Barber: "Intrinsic self-DNA triggers inflammatory disease dependent on STING." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 193, Issue 9, pp. 4634-42, (2014) (PubMed).

Target Details for CD11b

Target: CD11b (ITGAM) (Integrin alpha M (ITGAM))

Alternative Name: Cd11b/C (ITGAM Products)

Synonyms: CD11b/CD18 antibody, CR3 antibody, CR3A antibody, Cd11b antibody, F730045J24Rik antibody, Ly-40 antibody, MAC1 antibody, Mac-1 antibody, Mac-1a antibody, CD11B antibody, MAC-1 antibody, MAC1A antibody, MO1A antibody, SLEB6 antibody, C3bi antibody, integrin subunit alpha M antibody, integrin alpha M antibody, integrin, alpha M (complement component 3 receptor 3 subunit) antibody, integrin alpha-M antibody, ITGAM antibody, Itgam antibody, LOC100351865 antibody

Background:

Synonyms: CD11C, SLEB6, Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p15,95 alpha chain, Leukocyte adhesion receptor p15,95, ITGAX

Background: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

Gene ID: 3687

UniProt: P20702

Pathways: Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation