IL-6 antibody (AA 101-150)

Catalog No. ABIN739385

Product Details anti-IL-6 Antibody

Target: IL-6 (IL6) (Interleukin 6 (IL6))

Binding Specificity: AA 101-150

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse IL-6

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-IL-6 antibody (ABIN739385)

Ding, Ren, Yu, Yu, Zhou: "Porphyromonas gingivalis, a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice." in: Immunity & ageing : I & A, Vol. 15, pp. 6, (2018) (PubMed).

Xi, Wang, Chen, Yang, Hu, Zhang, Weng, Xu: "Expressions of IL-6, TNF-α and NF-κB in the skin of Chinese brown frog (Rana dybowskii)." in: European journal of histochemistry : EJH, Vol. 61, Issue 4, pp. 2834, (2018) (PubMed).

Ehrnthaller, Huber-Lang, Kovtun, Rapp, Kemmler, Gebhard, Ignatius: "C5aR inhibition in the early inflammatory phase does not affect bone regeneration in a model of uneventful fracture healing." in: European journal of medical research, Vol. 21, Issue 1, pp. 42, (2017) (PubMed).

Hong, Huang, Liu, Tsai: "Djulis (Chenopodium formosanum Koidz.) Water Extract and Its Bioactive Components Ameliorate Dermal Damage in UVB-Irradiated Skin Models." in: BioMed research international, Vol. 2016, pp. 7368797, (2017) (PubMed).

Chang, Chen, Hsu, Huang, Wu, Hsu: "Protective effects of the roots of Angelica sinensis on strenuous exercise-induced sports anemia in rats." in: Journal of ethnopharmacology, Vol. 193, pp. 169-178, (2016) (PubMed).

Wang, Gu, Liu, Bai, Wang: "Fluoxetine protects against methamphetamine‑induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats." in: Molecular medicine reports, Vol. 15, Issue 2, pp. 673-680, (2016) (PubMed).

Elkabir, El-Zehery, Mourad, Soliman, Helal, Refai, Grawish: "Efficacy of azithromycin and metronidazole combined therapy on rats' gingival overgrowth induced by cyclosporine-A: An experimental animal study." in: Journal of oral biology and craniofacial research, Vol. 6, Issue 3, pp. 219-226, (2016) (PubMed).

Kemmler, Bindl, McCook, Wagner, Gröger, Wagner, Scheuerle, Radermacher, Ignatius: "Exposure to 100% Oxygen Abolishes the Impairment of Fracture Healing after Thoracic Trauma." in: PLoS ONE, Vol. 10, Issue 7, pp. e0131194, (2016) (PubMed).

Li, Dan, Nie, Hu, Gesang, Bianba, Ze, Ciren: "CD14 knockdown reduces lipopolysaccharide-induced cell viability and expression of inflammation-associated genes in gastric cancer cells in vitro and in nude mouse xenografts." in: Molecular medicine reports, Vol. 12, Issue 3, pp. 4332-9, (2015) (PubMed).

Mohamed, El-Zehery, Mourad, Grawish: "Impact of three different mouthwashes on the incidence of gingival overgrowth induced by cyclosporine-A: a randomized controlled experimental animal study." in: Oral surgery, oral medicine, oral pathology and oral radiology, Vol. 120, Issue 3, pp. 346-56, (2015) (PubMed).

Chenna Narendra, Chalise, Magnusson, Uppugunduri: "Local but Not Systemic Administration of Uridine Prevents Development of Antigen-Induced Arthritis." in: PLoS ONE, Vol. 10, Issue 10, pp. e0141863, (2015) (PubMed).

Target Details for IL-6

Target: IL-6 (IL6) (Interleukin 6 (IL6))

Alternative Name: IL-6 (IL6 Products)

Synonyms: BSF2 antibody, HGF antibody, HSF antibody, IFNB2 antibody, IL-6 antibody, Il-6 antibody, ILg6 antibody, Ifnb2 antibody, il6 antibody, CHIL-6 antibody, interleukin 6 antibody, interleukin-6 antibody, IL6 antibody, Il6 antibody, il-6 antibody, IL-6 antibody

Background:

Synonyms: Il-6, Interleukin-6, B-cell hybridoma growth factor, Interleukin HP-1, Il6

Background: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

Gene ID: 16193

UniProt: P08505

Pathways: TLR Signaling, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome