MPZ antibody (AA 175-248)

Catalog No. ABIN738954

Product Details anti-MPZ Antibody

Target: MPZ (Myelin Protein Zero (MPZ))

Binding Specificity: AA 175-248

Reactivity: Rat, Mouse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MPZ antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: This antibody will recongize both isforms

Cross-Reactivity: Dog, Mouse, Rat

Predicted Reactivity: Human,Cow,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Myelin Protein Zero

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-MPZ antibody (ABIN738954)

Röhr, Halfter, Schulz, Young, Gess: "Sodium-dependent Vitamin C transporter 2 deficiency impairs myelination and remyelination after injury: Roles of collagen and demethylation." in: Glia, Vol. 65, Issue 7, pp. 1186-1200, (2017) (PubMed).

Schulz, Büttner, Hagel, Baader, Kluwe, Salamon, Mautner, Mindos, Parkinson, Gehlhausen, Clapp, Morrison: "The importance of nerve microenvironment for schwannoma development." in: Acta neuropathologica, Vol. 132, Issue 2, pp. 289-307, (2016) (PubMed).

Chitose, Sato, Fukahori, Sueyoshi, Kurita, Umeno: "Recurrent laryngeal nerve regeneration using an oriented collagen scaffold containing Schwann cells." in: The Laryngoscope, Vol. 127, Issue 7, pp. 1622-1627, (2016) (PubMed).

Schulz, Kyselyova, Baader, Jung, Zoch, Mautner, Hagel, Morrison: "Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling." in: Brain : a journal of neurology, Vol. 137, Issue Pt 2, pp. 420-32, (2014) (PubMed).

Li, Ma, Liu, Guo, Li, Li, Han, Wang, Wu: "Relationship between neural alteration and perineural invasion in pancreatic cancer patients with hyperglycemia." in: PLoS ONE, Vol. 6, Issue 2, pp. e17385, (2011) (PubMed).

Target Details for MPZ

Target: MPZ (Myelin Protein Zero (MPZ))

Alternative Name: Myelin Protein Zero (MPZ Products)

Background:

Synonyms: P, CHM, DSS, MPP, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, HMSNIB, Myelin protein P, Myelin peripheral protein, Myelin protein zero, MPZ

Background: Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.

Gene ID: 4359

UniProt: P25189