Integrin Alpha3, Beta1 (AA 976-1025) antibody

Catalog No. ABIN737031

Product Details

Target: Integrin Alpha3, Beta1

Binding Specificity: AA 976-1025

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: Mixed KLH conjugated synthetic peptide derived from human Integrin Alpha 3(976-1025/1051) + Beta 1(35-47/798)

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References

Wang, Zhang, Song, Wang, Guo, Zhang, Li, Han, Miao, Li: "PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion." in: Cell death & disease, Vol. 6, pp. e1682, (2015) (PubMed).

Target Details

Target: Integrin Alpha3, Beta1

Alternative Name: Integrin Alpha 3 + Beta 1

Background:

Synonyms: Integrin Alpha 3 / Beta 1, Integrin VLA 4 beta subunit, Alpha 3 subunit of VLA 3 receptor, CD29, CD49C, Fibronectin receptor, Fibronectin receptor beta subunit, Galactoprotein B3, GAPB3, VL3A, VLA 3 alpha chain, VLA3a.

Background: alpha3beta1 integrin is a laminin receptor with apparently diverse functions. In epithelial cells it acts as a receptor for the basement membrane, whereas in neuronal and possibly tumor cells it mediates migration. Interactions of alpha3beta1 integrin with tetraspanin proteins may provide clues to how it transduces signals that affect cell behavior.

Gene ID: 3675, 3688

UniProt: P26006, P05556