DUSP4 antibody (AA 301-394) (Biotin)

Catalog No. ABIN735385

Product Details anti-DUSP4 Antibody (Biotin)

Target: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Binding Specificity: AA 301-394

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP4 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MKP-2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for DUSP4

Target: DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))

Alternative Name: MKP-2/DUSP4 (DUSP4 Products)

Synonyms: zgc:55423 antibody, DUSP4 antibody, typ antibody, hvh2 antibody, mkp2 antibody, mkp-2 antibody, MGC131045 antibody, HVH2 antibody, MKP-2 antibody, MKP2 antibody, TYP antibody, 2700078F24Rik antibody, AI844617 antibody, BB104621 antibody, E130306H24Rik antibody, Mkp-2 antibody, Mkp2 antibody, dual specificity phosphatase 4 antibody, dual specificity phosphatase 4 S homeolog antibody, dusp4 antibody, DUSP4 antibody, dusp4.S antibody, Dusp4 antibody

Background:

Synonyms: Mitogen activated protein kinase phosphatase 2, Dual specicity phosphatase 4, Dual specicity protein phosphatase 4, Dual specicity protein phosphatase hVH2, DUSP 4, HVH 2, HVH2, MAP kinase phosphatase 2, Mitogen activated protein kinase phosphatase 2, MKP 2, MKP2, Serine/threonine specic protein phosphatase, TYP, VH 2, VH1 homologous phosphatase 2, VH2.

Background: DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

Gene ID: 1846

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades