HDAC3 antibody

Catalog No. ABIN734903

Product Details anti-HDAC3 Antibody

Target: HDAC3 (Histone Deacetylase 3 (HDAC3))

Reactivity: Human, Mouse, Rat, Dog, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HDAC3

Isotype: IgG

Application Details

Application Notes: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for HDAC3

Target: HDAC3 (Histone Deacetylase 3 (HDAC3))

Alternative Name: HDAC3/HD3 (HDAC3 Products)

Synonyms: CG2128 antibody, DHDAC3 antibody, DmHDAC3 antibody, Dmel\\CG2128 antibody, Dromel_CG2128_FBtr0078767_hdac3_mORF antibody, HDAC antibody, HDAC3 antibody, Hdac 3 antibody, dHDAC3 antibody, dmHDA402 antibody, hdac3 antibody, HDm antibody, hd3 antibody, RPD3 antibody, XRpd3 antibody, rpd3-2 antibody, HD3 antibody, RPD3-2 antibody, AW537363 antibody, zgc:55927 antibody, Histone deacetylase 3 antibody, histone deacetylase 3 antibody, histone deacetylase 3 S homeolog antibody, HDAC3 antibody, hdac3 antibody, CNL05260 antibody, Hdac3 antibody, hdac3.S antibody

Background:

Synonyms: HD3, RPD3, RPD3-2, Histone deacetylase 3, SMAP45, HDAC3

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP3 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.

Molecular Weight: 47kDa

Gene ID: 8841

UniProt: O15379

Pathways: Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development