FDCSP antibody (AA 18-85) (Biotin)

Catalog No. ABIN734155

Product Details anti-FDCSP Antibody (Biotin)

Target: FDCSP (C4orf7) (Chromosome 4 Open Reading Frame 7 (C4orf7))

Binding Specificity: AA 18-85

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FDCSP antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from rat FDC-SP

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for FDCSP

Target: FDCSP (C4orf7) (Chromosome 4 Open Reading Frame 7 (C4orf7))

Alternative Name: FDC-SP (C4orf7 Products)

Synonyms: FDC-SP antibody, C4orf7 antibody, cDNA sequence BC037156 antibody, follicular dendritic cell secreted protein antibody, BC037156 antibody, FDCSP antibody

Background:

Synonyms: FDC, FDCs, Follicular dendritic cell, Follicular dendritic cell secreted protein, Follicular dendritic cell, Follicular dendritic cell secreted peptide, FDC secreted protein.

Background: Follicular dendritic cells are cells that facilitate antigen recognition by B cells in follicles. This kind of dendritic cell is not bone marrow derived and is not a kind of blood cell. It is purely a resident of the follicles of secondary lymphoid organs. B cells form germinal centers around follicular dendritic cells in lymphoid organs. Dendritic cells form from monocytes, white blood cells which circulate in the body and, depending on the right signal, can turn into dendritic cells or macrophages. The monocytes in turn are formed from stem cells in the bone marrow.In normal tissue this antibody identifies dendritic cells and a proportion of B lymphocytes. Evidence in pathological tissue and functional studies suggests it binds to an epitope expressed by antigen presenting cells. Within the macrophage/dendritic cell populations the epitope seen by RFD1 is coexpressed with RFD7 by a subset of cells that exhibit suppressive activity on T cell stimulation.

Gene ID: 494224

UniProt: Q5R1M6