Ephrin A1 antibody (AA 101-205)

Catalog No. ABIN734108

Product Details anti-Ephrin A1 Antibody

Target: Ephrin A1 (EFNA1)

Binding Specificity: AA 101-205

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ephrin A1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Ephrin A1

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Ephrin A1

Target: Ephrin A1 (EFNA1)

Alternative Name: Ephrin A1 (EFNA1 Products)

Synonyms: Xefrin-A1 antibody, b61 antibody, ecklg antibody, efl1 antibody, efna1 antibody, efna1a antibody, elfa-a antibody, epha1 antibody, eplg1 antibody, lerk1 antibody, tnfaip4 antibody, xelf-a' antibody, xelfa antibody, AI325262 antibody, B61 antibody, Efl1 antibody, Epl1 antibody, Eplg1 antibody, Lerk1 antibody, ECKLG antibody, EFL1 antibody, EPLG1 antibody, LERK-1 antibody, LERK1 antibody, TNFAIP4 antibody, efna1b antibody, MGC130661 antibody, ephrin-A1 S homeolog antibody, ephrin-A1 antibody, ephrin A1 antibody, ephrin-A1b antibody, ephrin-A1 L homeolog antibody, efna1.S antibody, efna1 antibody, EFNA1 antibody, efna1b antibody, Efna1 antibody, efna1.L antibody

Background:

Synonyms: Ephrin-A1, EFNA1, EPH-related receptor tyrosine kinase ligand 1, LERK-1, Immediate early response protein B61, Tumor necrosis factor alpha-induced protein 4, EPLG1, LERK1, TNFAIP4

Background: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.

Gene ID: 1942

UniProt: P20827

Pathways: RTK Signaling