Cathepsin K antibody

Catalog No. ABIN732038

Product Details anti-Cathepsin K Antibody

Target: Cathepsin K (CTSK)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin K antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Capsin K

Isotype: IgG

Application Details

Application Notes: WB: 1:100-1000, IHC-P: 1:100-500, IF(IHC-P): 1:50-200
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Cathepsin K

Target: Cathepsin K (CTSK)

Alternative Name: Cathepsin K (CTSK Products)

Background:

Synonyms: Cathepsin K, Procathepsin K, Cathepsin K precursor, Cathepsin O, Cathepsin O1, Cathepsin O2, Cathepsin X, CathepsinK, CTS02, CTSK, CTSK protein, CTSO, CTSO1, CTSO2, MGC23107, PKND, PYCD, Pycnodysostosis, cath-K, CK.

Background: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq, Jul 2008].

Gene ID: 1513

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades