VCAM1 antibody (AA 651-739)

Catalog No. ABIN729838

Product Details anti-VCAM1 Antibody

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Binding Specificity: AA 651-739

Reactivity: Human, Mouse, Rat, Rabbit, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VCAM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rabbit, Rat, Sheep

Predicted Reactivity: Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human VCAM-1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-VCAM1 antibody (ABIN729838)

Kim, Lee, Yeon, Park, Yang: "Effects of silk fibroin in murine dry eye." in: Scientific reports, Vol. 7, pp. 44364, (2017) (PubMed).

Bartko, Dal-Bianco, Guerrero, Beaudoin, Szymanski, Kim, Seybolt, Handschumacher, Sullivan, Garcia, Titus, Wylie-Sears, Irvin, Messas, Hagège, Carpentier, Aikawa, Bischoff, Levine: "Effect of Losartan on Mitral Valve Changes After Myocardial Infarction." in: Journal of the American College of Cardiology, Vol. 70, Issue 10, pp. 1232-1244, (2017) (PubMed).

Vendrov, Stevenson, Alahari, Pan, Wickline, Madamanchi, Runge: "Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice." in: Journal of the American Heart Association, Vol. 6, Issue 11, (2017) (PubMed).

Tang, Ni, Cai, Ding, Liu, Zhang et al.: "Renoprotective effects of berberine and its potential effect on the expression of β-arrestins and intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in streptozocin-diabetic ..." in: Journal of diabetes, Vol. 8, Issue 5, pp. 693-700, (2016) (PubMed).

Lozhkin, Vendrov, Pan, Wickline, Madamanchi, Runge: "NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis." in: Journal of molecular and cellular cardiology, Vol. 102, pp. 10-21, (2016) (PubMed).

Mu, Chen, Gong, Zheng, Xing: "Expression of vascular cell adhesion molecule-1 in the aortic tissues of atherosclerotic patients and the associated clinical implications." in: Experimental and therapeutic medicine, Vol. 10, Issue 2, pp. 423-428, (2015) (PubMed).

Lee, Lee, Huang, Chang, Lin, Chien, Yang, Lin: "Comparison of Surface Markers between Human and Rabbit Mesenchymal Stem Cells." in: PLoS ONE, Vol. 9, Issue 11, pp. e111390, (2014) (PubMed).

Ma, Niu, Sun, Wang, Luo, Zhang, Wang: "Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta." in: Archives of toxicology, Vol. 86, Issue 6, pp. 849-56, (2012) (PubMed).

Target Details for VCAM1

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Alternative Name: VCAM1 (VCAM1 Products)

Synonyms: CD106 antibody, INCAM-100 antibody, Vcam-1 antibody, VCAM1B antibody, fi76d06 antibody, wu:fi76d06 antibody, zgc:158875 antibody, VCAM1 antibody, vascular cell adhesion molecule 1 antibody, vascular cell adhesion molecule 1b antibody, VCAM1 antibody, Vcam1 antibody, vcam1b antibody, VCAM-1 antibody

Background:

Synonyms: CD106, INCAM-1, Vascular cell adhesion protein 1, V-CAM 1, VCAM-1, VCAM1, L1CAM

Background: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

Gene ID: 7412

UniProt: P19320

Pathways: Carbohydrate Homeostasis