CGRP antibody (AA 65-130)

Catalog No. ABIN728218

Product Details anti-CGRP Antibody

Target: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Binding Specificity: AA 65-130

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CGRP antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse,Cow,Pig,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CALCA

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CGRP antibody (ABIN728218)

He, Xiong, Liu, He, Feng, Shang, Xia, Wang, Qiu, Luo, Liu, Wang: "MicroRNA-127 targeting of mitoNEET inhibits neurite outgrowth, induces cell apoptosis and contributes to physiological dysfunction after spinal cord transection." in: Scientific reports, Vol. 6, pp. 35205, (2016) (PubMed).

Liu, Peng, Long, Li, Ke, Fang: "Mutual effect between neuropeptides and inflammatory cytokines in neurogenic SMSCs of human temporomandibular joint." in: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 34, Issue 4, pp. 602-7, (2014) (PubMed).

Wang, Sun, Tang, Guo, Zhou, Chen, Shen: "Basic fibroblast growth factor attenuates the degeneration of injured spinal cord motor endplates." in: Neural regeneration research, Vol. 8, Issue 24, pp. 2213-24, (2014) (PubMed).

Tu, Li, Peng, Hu, Liu, Kong, Liu, Gao, Xu, Xu, Qiu, Fan, Zhu, Yu, Zheng, Wu, Peng, Song, Wu, Liang: "P2X(7) inhibition in stellate ganglia prevents the increased sympathoexcitatory reflex via sensory-sympathetic coupling induced by myocardial ischemic injury." in: Brain research bulletin, Vol. 96, pp. 71-85, (2013) (PubMed).

Liu, Li, Peng, Tu, Kong, Liu, Gao, Xu, Qiu, Fan, Zhu, Yu, Zheng, Wu, Peng, Song, Wu, Li, Liang: "Sensory-sympathetic coupling in superior cervical ganglia after myocardial ischemic injury facilitates sympathoexcitatory action via P2X7 receptor." in: Purinergic signalling, Vol. 9, Issue 3, pp. 463-79, (2013) (PubMed).

Li, Zhang, Zhang, Ma: "The protective effect of genistein postconditioning on hypoxia/reoxygenation-induced injury in human gastric epithelial cells." in: Acta pharmacologica Sinica, Vol. 30, Issue 5, pp. 576-81, (2009) (PubMed).

Target Details for CGRP

Target: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Alternative Name: CGRP (CALCA Products)

Synonyms: CALC1 antibody, CGRP antibody, CGRP-I antibody, CGRP1 antibody, CT antibody, KC antibody, CALC antibody, CALCA antibody, CALC3 antibody, ci-ct antibody, calca antibody, CA antibody, CGRP-1 antibody, Calc antibody, Calc1 antibody, Cgrp antibody, Ct antibody, Ctn antibody, calcitonin antibody, CAL6 antibody, Cal1 antibody, RATCAL6 antibody, CGRPI antibody, calc antibody, cgrp antibody, zgc:92886 antibody, calcitonin related polypeptide alpha antibody, calcitonin related polypeptide beta antibody, calcitonin-related polypeptide alpha antibody, calcitonin antibody, calcitonin/calcitonin-related polypeptide, alpha antibody, calcitonin-related polypeptide beta antibody, calcitonin gene-related peptide 2 antibody, CALCA antibody, CALCB antibody, ci-ct antibody, calca antibody, Calca antibody, LOC100008771 antibody

Background:

Synonyms: CAL6, CGRP, Cal1, Calc, RATCAL6, calcitonin, Calcitonin gene-related peptide 1, Alpha-type CGRP, Calcitonin gene-related peptide I, CGRP-I, Calca

Background: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

Gene ID: 24241

UniProt: P06881

Pathways: Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour