SHANK1 antibody (AA 101-200)

Catalog No. ABIN726335

Product Details anti-SHANK1 Antibody

Target: SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1))

Binding Specificity: AA 101-200

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHANK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Shank1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-SHANK1 antibody (ABIN726335)

Zhang, Zheng, Wan, Shao, Liu, Zhang, Zhang: "The potential use of H102 peptide-loaded dual-functional nanoparticles in the treatment of Alzheimer's disease." in: Journal of controlled release : official journal of the Controlled Release Society, Vol. 192, pp. 317-24, (2014) (PubMed).

Target Details for SHANK1

Target: SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1))

Alternative Name: SHANK 1 (SHANK1 Products)

Synonyms: SPANK-1 antibody, SSTRIP antibody, synamon antibody, Shank1a antibody, Spank1 antibody, Sstrip antibody, SH3 and multiple ankyrin repeat domains 1 antibody, SHANK1 antibody, Shank1 antibody

Background:

Synonyms: SSTRIP, SPANK-1, synamon, SH3 and multiple ankyrin repeat domains protein 1, Shank1, Somatostatin receptor-interacting protein, SSTR-interacting protein

Background: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.

Gene ID: 50944

UniProt: Q9Y566

Pathways: Synaptic Membrane, Maintenance of Protein Location