CD31 antibody (AA 681-738)

Catalog No. ABIN726140

Product Details anti-CD31 Antibody

Target: CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

Binding Specificity: AA 681-738

Reactivity: Human, Mouse, Rat, Rabbit, Pig, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD31 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Cross-Reactivity: Cow, Human, Mouse, Pig, Rabbit, Rat

Predicted Reactivity: Dog,Sheep

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CD31

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CD31 antibody (ABIN726140)

Kong, Lee, Youm, Kim, Lee, Suh, Kim: "Effect of treatment with angiopoietin-2 and vascular endothelial growth factor on the quality of xenografted bovine ovarian tissue in mice." in: PLoS ONE, Vol. 12, Issue 9, pp. e0184546, (2018) (PubMed).

Brumm, Nunez, Doroudchi, Kawaguchi, Duan, Pellegrini, Lam, Carmichael, Deb, Hinman: "Astrocytes Can Adopt Endothelial Cell Fates in a p53-Dependent Manner." in: Molecular neurobiology, Vol. 54, Issue 6, pp. 4584-4596, (2018) (PubMed).

Lee, Lee, Lee, Choi, Yang: "Chondrocyte-derived extracellular matrix suppresses pathogenesis of human pterygium epithelial cells by blocking the NF-κB signaling pathways." in: Molecular vision, Vol. 22, pp. 1490-1502, (2018) (PubMed).

Wang, Chen, Wang, Shi, Wang, Zhang, Gao, Li, Qi, An, Chen: "Targeting neurokinin-3 receptor: a novel anti-angiogenesis strategy for cancer treatment." in: Oncotarget, Vol. 8, Issue 25, pp. 40713-40723, (2018) (PubMed).

Wang, Chen, Ke, Li: "Ghrelin inhibits atherosclerotic plaque angiogenesis and promotes plaque stability in a rabbit atherosclerotic model." in: Peptides, Vol. 90, pp. 17-26, (2017) (PubMed).

Korkmaz, Ulrich, Vogels, de Wit, van Zuijlen, Krijnen, Niessen: "Neutrophil extracellular traps coincide with a pro-coagulant status of microcirculatory endothelium in burn wounds." in: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, Vol. 25, Issue 4, pp. 609-617, (2017) (PubMed).

Wu, Zhang, Ye, Shen, Liu, Hu, Li, Wu, Chen, Zhou: "Overexpression and correlation of HIF-2α, VEGFA and EphA2 in residual hepatocellular carcinoma following high-intensity focused ultrasound treatment: Implications for tumor recurrence and progression." in: Experimental and therapeutic medicine, Vol. 13, Issue 6, pp. 3529-3534, (2017) (PubMed).

Yang, Pei, Wang, Jin, Yu, Zhou, Zhang, Zhang, Lin: "Tiamulin inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of CD73." in: BMC cancer, Vol. 17, Issue 1, pp. 255, (2017) (PubMed).

Schuerlein, Schwarz, Krziminski, Gätzner, Hoppensack, Schwedhelm, Schweinlin, Walles, Hansmann: "A versatile modular bioreactor platform for Tissue Engineering." in: Biotechnology journal, (2016) (PubMed).

Struecker, Hillebrandt, Raschzok, Jöhrens, Butter, Tang, Andreou, Napierala, Reutzel-Selke, Denecke, Pratschke, Sauer: "Implantation of a Tissue-Engineered Neo-Bile Duct in Domestic Pigs." in: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes, Vol. 56, Issue 1-2, pp. 61-75, (2016) (PubMed).

Ji, Zhang, Chen, Che, Zhou, Wang: "Sodium humate accelerates cutaneous wound healing by activating TGF-β/Smads signaling pathway in rats." in: Acta pharmaceutica Sinica. B, Vol. 6, Issue 2, pp. 132-40, (2016) (PubMed).

Pei, Yang, Wang, Zhang, Zhou, Zhang, Lin: "Plantamajoside, a potential anti-tumor herbal medicine inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of matrix metalloproteinase-9 and -2." in: BMC cancer, Vol. 15, pp. 965, (2016) (PubMed).

Xiang, Zheng, Zhou, Qiao, Tran, Pu, Li, Kong, Kouzani, Lin, Liu, Li, Shigdar, Duan: "Superior Performance of Aptamer in Tumor Penetration over Antibody: Implication of Aptamer-Based Theranostics in Solid Tumors." in: Theranostics, Vol. 5, Issue 10, pp. 1083-97, (2015) (PubMed).

Karaca, Hulya Uz, Karabacak, Karaboga, Demirtas, Cagatay Cicek: "Effects of hyperthyroidism on expression of vascular endothelial growth factor (VEGF) and apoptosis in fetal adrenal glands." in: European journal of histochemistry : EJH, Vol. 59, Issue 4, pp. 2560, (2015) (PubMed).

Sun, Ni, Sun, Cai, Yu, Wang, Nie, Sun, Ni, Cao: "Adipose-Derived Stem Cells Alleviate Radiation-Induced Muscular Fibrosis by Suppressing the Expression of TGF-β1." in: Stem cells international, Vol. 2016, pp. 5638204, (2015) (PubMed).

Lee, Lee, Yang: "Effect of porcine chondrocyte-derived extracellular matrix on the pterygium in mouse model." in: Graefe's archive for clinical and experimental ophthalmology, Vol. 252, Issue 4, pp. 609-18, (2014) (PubMed).

Liu, Xue, Li, Zhang, Fu, Feng, Chen, Xu: "Amelioration of stroke-induced neurological deficiency by lyophilized powder of catapol and puerarin." in: International journal of biological sciences, Vol. 10, Issue 4, pp. 448-56, (2014) (PubMed).

Choi, Choi, Lee, Song, Park, Yang, Min: "Inhibition of blood vessel formation by a chondrocyte-derived extracellular matrix." in: Biomaterials, Vol. 35, Issue 22, pp. 5711-20, (2014) (PubMed).

Lee, Lee, Kim, Yang: "Anti-neovascular effect of chondrocyte-derived extracellular matrix on corneal alkaline burns in rabbits." in: Graefe's archive for clinical and experimental ophthalmology, Vol. 252, Issue 6, pp. 951-61, (2014) (PubMed).

Target Details for CD31

Target: CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

Alternative Name: CD31 (PECAM1 Products)

Synonyms: CD31 antibody, CD31/EndoCAM antibody, GPIIA' antibody, PECA1 antibody, PECAM-1 antibody, endoCAM antibody, C85791 antibody, Cd31 antibody, Pecam antibody, platelet/endothelial cell adhesion molecule 1 antibody, platelet and endothelial cell adhesion molecule 1 antibody, pecam1 antibody, PECAM1 antibody, Pecam1 antibody

Background:

Synonyms: CD31, PECA1, GPIIA', PECAM-1, endoCAM, CD31/EndoCAM, Platelet endothelial cell adhesion molecule, PECAM1

Background: Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-69 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

Gene ID: 5175

UniProt: P16284

Pathways: Regulation of Actin Filament Polymerization