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Caspase 1 (p10) antibody (AA 320-404)

CASP-1 (p10) Reactivity: Human, Mouse, Rat, Chicken WB, FACS, IF (cc), IF (p), ELISA, IHC (fro), IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN725780
  • Target See all Caspase 1 (p10) (CASP-1 (p10)) products
    Caspase 1 (p10) (CASP-1 (p10))
    Binding Specificity
    • 16
    • 15
    • 15
    • 1
    AA 320-404
    Reactivity
    Human, Mouse, Rat, Chicken
    Host
    • 47
    • 2
    Rabbit
    Clonality
    • 47
    • 2
    Polyclonal
    Conjugate
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    This Caspase 1 (p10) antibody is un-conjugated
    Application
    • 49
    • 27
    • 25
    • 25
    • 8
    • 5
    • 5
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Chicken, Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Caspase-1
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Daverey, Agrawal: "Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes." in: Neuroscience, Vol. 333, pp. 92-103, (2016) (PubMed).

    Wang, Lei, Zhang, Zhao, Fang, Lai, Han, Xiao, Wang: "Xenobiotic Pregnane X Receptor (PXR) Regulates Innate Immunity via Activation of NLRP3 Inflammasome in Vascular Endothelial Cells." in: The Journal of biological chemistry, Vol. 289, Issue 43, pp. 30075-81, (2014) (PubMed).

    Yao, Wigginton, Maass, Ma, Carlson, Wolf, Minei, Zang: "Estrogen-provided cardiac protection following burn trauma is mediated through a reduction in mitochondria-derived DAMPs." in: American journal of physiology. Heart and circulatory physiology, Vol. 306, Issue 6, pp. H882-94, (2014) (PubMed).

    Hu, Kang, Chen, Mamuti, Wu, Yuan: "Drug-induced apoptosis of Echinococcus granulosus protoscoleces." in: Parasitology research, Vol. 109, Issue 2, pp. 453-9, (2011) (PubMed).

  • Target
    Caspase 1 (p10) (CASP-1 (p10))
    Alternative Name
    Caspase-1 P10 (CASP-1 (p10) Products)
    Background

    Synonyms: ICE, P45, IL1BC, Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, IL-1 beta-converting enzyme, CASP1, IL1BCE

    Background: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

    Gene ID
    834
    UniProt
    P29466
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