Caspase 1 (p10) antibody (AA 320-404)
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- Target See all Caspase 1 (p10) (CASP-1 (p10)) products
- Caspase 1 (p10) (CASP-1 (p10))
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Binding Specificity
- AA 320-404
- Reactivity
- Human, Mouse, Rat, Chicken
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Caspase 1 (p10) antibody is un-conjugated
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Chicken, Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Caspase-1
- Isotype
- IgG
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes." in: Neuroscience, Vol. 333, pp. 92-103, (2016) (PubMed).
: "Xenobiotic Pregnane X Receptor (PXR) Regulates Innate Immunity via Activation of NLRP3 Inflammasome in Vascular Endothelial Cells." in: The Journal of biological chemistry, Vol. 289, Issue 43, pp. 30075-81, (2014) (PubMed).
: "Estrogen-provided cardiac protection following burn trauma is mediated through a reduction in mitochondria-derived DAMPs." in: American journal of physiology. Heart and circulatory physiology, Vol. 306, Issue 6, pp. H882-94, (2014) (PubMed).
: "Drug-induced apoptosis of Echinococcus granulosus protoscoleces." in: Parasitology research, Vol. 109, Issue 2, pp. 453-9, (2011) (PubMed).
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Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes." in: Neuroscience, Vol. 333, pp. 92-103, (2016) (PubMed).
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- Target
- Caspase 1 (p10) (CASP-1 (p10))
- Alternative Name
- Caspase-1 P10 (CASP-1 (p10) Products)
- Background
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Synonyms: ICE, P45, IL1BC, Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, IL-1 beta-converting enzyme, CASP1, IL1BCE
Background: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
- Gene ID
- 834
- UniProt
- P29466
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