GCH1 antibody (AA 34-110)

Catalog No. ABIN725510

Product Details anti-GCH1 Antibody

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Binding Specificity: AA 34-110

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GCH1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GTP-CH-1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for GCH1

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Alternative Name: GTP cyclohydrolase 1 (GCH1 Products)

Synonyms: DYT14 antibody, DYT5 antibody, DYT5a antibody, GCH antibody, GTP-CH-1 antibody, GTPCH1 antibody, HPABH4B antibody, GTP-CH antibody, GTPCH antibody, Gch antibody, MGC89622 antibody, gch1a antibody, wu:fc16b10 antibody, zgc:195269 antibody, GTP cyclohydrolase 1 antibody, GTP cyclohydrolase 1-like antibody, GCH1 antibody, Gch1 antibody, gch1 antibody, Weevi_1190 antibody, Halhy_0838 antibody, Sinme_1220 antibody, Sphch_1077 antibody, LOC100136794 antibody

Background:

Synonyms: GTP-CH-1, DYT 5, DYT5, GCH 1, GCH, GCH1, GTP CH 1, GTP CH I, GTP cyclohydrolase 1 dopa responsive dystonia, GTP cyclohydrolase 1, GTP cyclohydrolase I, GTPCH 1, GTPCH1, Guanosine 5' triphosphate cyclohydrolase I.

Background: GTP cyclohydrolase I (also designated dopa-responsive dystonia) catalyzes the conversion of GTP to D-erythro-7,8-dihydroneopterin triphosphate, the first and rate-limiting step in tetrahydrobiopterin (BH4) biosynthesis. Tetrahydrobiopterin is an essential cofactor for 3 aromatic amino acid monooxygenases: phenylalanine, tyrosine, and tryptophan hydroxylases. Animals can synthesize tetrahydrobiopterin in vivo from GTP through several enzymatic reactions.

Gene ID: 2643