Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

SOCS1 antibody (AA 121-211)

SOCS1 Reactivity: Human ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN725135
  • Target See all SOCS1 Antibodies
    SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
    Binding Specificity
    • 14
    • 13
    • 8
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 121-211
    Reactivity
    • 67
    • 37
    • 31
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    Human
    Host
    • 64
    • 5
    • 2
    Rabbit
    Clonality
    • 67
    • 4
    Polyclonal
    Conjugate
    • 37
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SOCS1 antibody is un-conjugated
    Application
    • 41
    • 21
    • 17
    • 12
    • 12
    • 11
    • 10
    • 9
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human
    Predicted Reactivity
    Mouse,Rat,Cow,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Socs 1
    Isotype
    IgG
    Top Product
    Discover our top product SOCS1 Primary Antibody
  • Application Notes
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))
    Alternative Name
    SOCS1 (SOCS1 Products)
    Synonyms
    socs1 antibody, zgc:91868 antibody, jab antibody, cis1 antibody, ssi1 antibody, tip3 antibody, cish1 antibody, ssi-1 antibody, socs-1 antibody, SOCS1 antibody, LOC100228306 antibody, socs1b antibody, CIS1 antibody, CISH1 antibody, JAB antibody, SOCS-1 antibody, SSI-1 antibody, SSI1 antibody, TIP3 antibody, Cish1 antibody, Cish7 antibody, Socs-1 antibody, suppressor of cytokine signaling 1a antibody, suppressor of cytokine signaling 1 antibody, suppressor of cytokine signaling 1 L homeolog antibody, socs1a antibody, socs1 antibody, SOCS1 antibody, socs1.L antibody, Socs1 antibody
    Background

    Synonyms: JAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1, Suppressor of cytokine signaling 1, JAK-binding protein, STAT-induced STAT inhibitor 1, Tec-interacting protein 3, TIP-3, SOCS1

    Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

    Gene ID
    8651
    UniProt
    O15524
    Pathways
    JAK-STAT Signaling, Interferon-gamma Pathway, TLR Signaling, Response to Growth Hormone Stimulus
You are here:
Support