Amylin/DAP antibody

Catalog No. ABIN724280

Product Details anti-Amylin/DAP Antibody

Target: Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Amylin/DAP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Amylin

Isotype: IgG

Application Details

Application Notes: WB: (1:100-1000), IHC-P: (1:100-500), IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Amylin/DAP

Target: Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))

Alternative Name: Amylin (IAPP Products)

Synonyms: DAP antibody, IAP antibody, LOC100230121 antibody, Amylin antibody, islet amyloid polypeptide antibody, IAPP antibody, Iapp antibody

Background:

Synonyms: Islet amyloid polypeptide, IAPP, DAP, Diabetes associated peptide, IAP, Insulinoma amyloid peptide.

Background: Amylin is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the assosciation of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Recent results suggest that amylin, like the related beta amyloid (Abeta) assosciated with Alzheimer's disease, can induce apoptotic cell death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.

Gene ID: 3375

Pathways: Hormone Activity, Feeding Behaviour