Recombinant TCR beta antibody

Catalog No. ABIN7543083

Product Details anti-TCR beta Antibody

Target: TCR beta (T Cell Receptor (TCR) beta (TCR beta))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This TCR beta antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), ELISA

Purpose: Anti-TCR beta [IARC307], Rabbit IgG, kappa

Specificity: This antibody is specific for Vbeta8.1 CDR1 sequence CKPISGHNSLFQWYRQT.

Characteristics:

Original Species of Ab: Human

Original Format of Ab: IgM

Purification: Protein A affinity purified

Immunogen: Derived from normal B cells in peripheral blood of a Burkitt's lymphoma patient. Screened more than 60 culture supernatants from lymphoblastoid cell lines of normal origin, Epstein-Barr virus (EBV)-carrying Burkitt lymphomas, EBV-negative Burkitt lymphomas and EBV-converted sublines of original EBV-negative Burkitt lymphoma human B-cell lines for their capacity to bind the synthetic peptide autoantigens. One lymphoblastoid B-cell line was identified, IARC307, that produces IgM kappa antibodies which specifically react with the CDR1 peptide corresponding to human Vbeta8.1 gene sequence.

Clone: IARC307

Isotype: IgG kappa

Application Details

Application Notes: IARC307 has been used in ELISAs to bind to synthetic peptides of CRD1 region from several TCR Vbeta families of man and mouse (Marchalonis 2000).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgM format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for TCR beta

Target: TCR beta (T Cell Receptor (TCR) beta (TCR beta))

Alternative Name: TCR beta (TCR beta Products)

Background: IARC-307, TCR-beta, T cell receptor, T-cell receptor, T cell receptor beta chain, TCRB, TRB, TCB1, Ti, TCR V beta, IARC/307, IARC 307

UniProt: P01850, A0A5B9