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Recombinant SIRPG antibody

SIRPG Reactivity: Human ELISA, FACS, IP, BR Host: Mouse Monoclonal OX-119 unconjugated Recombinant Antibody
Catalog No. ABIN7543054
  • Target See all SIRPG Antibodies
    SIRPG (Signal-Regulatory Protein gamma (SIRPG))
    Antibody Type
    Recombinant Antibody
    Reactivity
    • 45
    • 7
    • 7
    • 3
    • 3
    • 1
    Human
    Host
    • 30
    • 15
    Mouse
    Clonality
    • 30
    • 14
    • 1
    Monoclonal
    Conjugate
    • 25
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SIRPG antibody is un-conjugated
    Application
    • 24
    • 17
    • 14
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Reagent (BR)
    Purpose
    Anti-SIRP g [OX-119], Mouse IgG1, kappa
    Specificity
    Hybridoma supernatants were initially screened by ELISA, using SIRPg-CD4, human SIRPa-Fc, human SIRPb-Fc or CD4 to eliminate hybridomas with cross-reactivity to rat CD4, human SIRPa, and SIRPb. There is some marginal binding of OX-119 to SIRPb transfected 293T cells. SIRPg binds CD47. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells..
    Characteristics

    Original Species of Ab: Mouse

    Original Format of Ab: IgG1

    Purification
    Protein A affinity purified
    Immunogen
    OX-119 was prepared by immunizing BALB/c mice with a chimeric protein made up of human SIRPg and a leader peptide of rat CD4 domain (SIRPg-CD4 ).
    Clone
    OX-119
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product SIRPG Primary Antibody
  • Application Notes
    OX-119 is able to perform staining of peripheral blood myeloid cells (PBMCs) and block SIRPg-mediated apoptosis. OX-119 can also be used in IP, FC and ELISA.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % Proclin 300.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • Target
    SIRPG (Signal-Regulatory Protein gamma (SIRPG))
    Alternative Name
    SIRP g (SIRPG Products)
    Background
    CD172g, OX119, MRC OX-119, MRC OX119, SIRP-g, SIRPg, SIRP gamma, SIRP-gamma, CD172 antigen-like family member B, signal-regulatory protein beta, CD172-g
    UniProt
    Q9P1W8
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