Recombinant CD40L (Ruplizumab Biosimilar) antibody
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- Target See all CD40L (Ruplizumab Biosimilar) products
- CD40L (Ruplizumab Biosimilar)
- Antibody Type
- Recombinant Antibody
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Chimeric
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Conjugate
- This CD40L (Ruplizumab Biosimilar) antibody is un-conjugated
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Application
- Flow Cytometry (FACS), Western Blotting (WB), Blocking Reagent (BR)
- Purpose
- Anti-CD40L [hu5c8 (Ruplizumab)], Mouse IgG2a, kappa
- Specificity
- The antibody binds to CD40L with an IC50 of 0.845 μg/mL.
- Characteristics
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Original Species of Ab: Human
Original Format of Ab: IgG1
- Purification
- Protein A affinity purified
- Immunogen
- Human CD40L
- Clone
- Hu5c8
- Isotype
- IgG2a kappa
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anti-CD40L (Ruplizumab Biosimilar) antibody
Research Grade Reactivity: Human FACS, ELISA Host: Humanized Monoclonal unconjugated Recombinant Antibody
anti-CD40L (Ruplizumab Biosimilar) antibodyReactivity: Human FACS, WB, BR Host: Human Monoclonal hu5c8 unconjugated Recombinant Antibody
anti-CD40L (Ruplizumab Biosimilar) antibodyReactivity: Human FACS, WB, BR Host: Rabbit Chimeric hu5c8 unconjugated Recombinant Antibody
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- Application Notes
- The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralises CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the original therapeutic antibody was found to have a T1/2 of 531 ± 155 hours.
- Comment
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This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % Proclin 300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Target
- CD40L (Ruplizumab Biosimilar)
- Abstract
- CD40L (Ruplizumab Biosimilar) Products
- Target Type
- Biosimilar
- Background
- CD154, CD40 ligand, tumour necrosis factor ligand superfamily member 5, TNFSF5, tumour necrosis factor related activation protein, TRAP
- UniProt
- P29965
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