Recombinant CD33 (Gemtuzumab Biosimilar) antibody

Catalog No. ABIN7542953

Product Details anti-CD33 (Gemtuzumab Biosimilar) Antibody

Target: CD33 (Gemtuzumab Biosimilar)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Chimeric

Conjugate: This CD33 (Gemtuzumab Biosimilar) antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Purpose: Anti-CD33 [hP67.6 (Gemtuzumab)], Mouse IgG1, kappa

Specificity: Recognises human CD33.

Characteristics:

Original Species of Ab: Human

Original Format of Ab: IgG4

Purification: Protein A affinity purified

Immunogen: Gemtuzumab was generated by huminization of the murine P67.6 clone, raised against CD33-transfected FMY9S5 cells of human origin. CD33 is a transmembrane receptor expressed on predominantly on cells of the myeloid lineage, but it can also be found on some lymphoid cells.

Clone: HP67-6

Isotype: IgG1 kappa

Application Details

Application Notes: A human IgG4 variant conjugated to derivative of the cytotoxic drug calicheamicin gamma 1, N-acetylcalicheamicin dimethyl hydrazide, has been used as a therapeutic against acute myeloid leukemia. This antibody may also be used in flow cytometry and immunofluorescence.

Comment:

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for CD33 (Gemtuzumab Biosimilar)

Target: CD33 (Gemtuzumab Biosimilar)

Abstract: CD33 (Gemtuzumab Biosimilar) Products

Target Type: Biosimilar

Background: Siglec-3

UniProt: P20138