Recombinant TNF alpha (Infliximab Biosimilar) antibody

Catalog No. ABIN7542939

Product Details anti-TNF alpha (Infliximab Biosimilar) Antibody

Target: TNF alpha (Infliximab Biosimilar)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Chimeric

Conjugate: This TNF alpha (Infliximab Biosimilar) antibody is un-conjugated

Application: Flow Cytometry (FACS), In vivo Studies (in vivo), ELISA

Purpose: Anti-TNF alpha [cA2 (Infliximab)], Mouse IgG2a, kappa

Specificity: Binds to soluble and transmembrane forms of TNF-alpha and neutralizes its biological activity. Does not bind to TNF-beta.

Characteristics:

Original Species of Ab: Human

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: Purified recombinant human TNF (rTNF).

Clone: CA2

Isotype: IgG2a kappa

Application Details

Application Notes: This antibody can be used to detect and neutralize human TNF alpha. Unlike Adalimumab (Ab00718), Infliximab does not bind to mouse TNF alpha (Arnoult 2017, PMID: 28584008).

Comment:

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for TNF alpha (Infliximab Biosimilar)

Target: TNF alpha (Infliximab Biosimilar)

Abstract: TNF alpha (Infliximab Biosimilar) Products

Target Type: Biosimilar

Background: TNF-α, TNFα, TNFSF, Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, TNFa

UniProt: P01375