Recombinant ErbB2/Her2 (Trastuzumab Biosimilar) antibody
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- Target See all ErbB2/Her2 (Trastuzumab Biosimilar) products
- ErbB2/Her2 (Trastuzumab Biosimilar)
- Antibody Type
- Recombinant Antibody
- Reactivity
- Human
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Host
- Mouse
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Clonality
- Chimeric
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Conjugate
- This ErbB2/Her2 (Trastuzumab Biosimilar) antibody is un-conjugated
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Application
- Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)
- Purpose
- Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)], Mouse IgG2a, kappa
- Specificity
- Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30 % of invasive breast cancers and 70 % of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder.
- Characteristics
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Original Species of Ab: Human
Original Format of Ab: IgG1
- Purification
- Protein A affinity purified
- Immunogen
- A431 cells (human epidermoid carcinoma) (over)expressing EGFR.
- Clone
- 4D5-8
- Isotype
- IgG2a kappa
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anti-ErbB2/Her2 (Trastuzumab Biosimilar) antibody
Research Grade Reactivity: Human FACS, ELISA Host: Humanized Monoclonal unconjugated Recombinant Antibody
anti-ErbB2/Her2 (Trastuzumab Biosimilar) antibodyReactivity: Human FACS, ELISA, IHC Host: Rabbit Chimeric 4D5-8 unconjugated Recombinant Antibody
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- Application Notes
- This antibody binds to erbB-2/Her-2/neu has therapeutic indications particularly in the treatment of breast cancer (c.f. Herceptin). It can also be used to detect HER-2 by flow cytometry or IHC (Glazyrin 2007).
- Comment
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This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % Proclin 300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Target
- ErbB2/Her2 (Trastuzumab Biosimilar)
- Abstract
- ErbB2/Her2 (Trastuzumab Biosimilar) Products
- Target Type
- Biosimilar
- Background
- CD340, Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, p185HER2, EGFR
- UniProt
- P04626
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