EBV LMP1 antibody

Catalog No. ABIN7540659

Supplier Product No.: mob194-01

Product Details anti-EBV LMP1 Antibody

Target: EBV LMP1 (Epstein-Barr Virus Latent Membrane Protein 1 (EBV LMP1))

Reactivity: Epstein-Barr Virus (EBV)

Host: Mouse

Clonality: Monoclonal

Conjugate: This EBV LMP1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Supplier Product No.: mob194-01

Supplier: Rockland

Purpose: LMP-1 (Epstein-Barr Virus) Monoclonal Antibody

Cross-Reactivity (Details): This antibody is specific to 60 kDa latent membrane protein (LMP-1) encoded by the BNLF1 gene of the EBV.

Purification: The antibody was clarified from tissue culture supernatant.

Immunogen: Anti-LMP-1 (Epstein-Barr Virus) antibody was produced in mice by repeated immunizations with recombinant fusion protein containing sequences of bacterial beta-galactosidase and EBV encoded latent membrane protein.

Clone: CS1-CS2-CS3-CS4

Isotype: IgG1

Application Details

Application Notes: Optional[Neutralization_Dilution]: 1:50-1:100

Comment:

Anti-LMP-1 (Epstein-Barr Virus) (MOUSE) Monoclonal Antibody was tested in IHC-P with positive control infected lymphoblastoma, Hodgkin's lymphoma tissues. Cellular Localization: Cytoplasmic. The user is advised to validate the use of the products with their tissue specimens prepared and handled in accordance with their laboratory practices. This antibody stains strongly with EBV positive lymphoblastoid cell lines and EBV infected B cell immunoblasts in infectious mononucleosis. Consult references (Kiernan, 1981: Sheehan & Hrapchak, 1980) for further details on specimen preparation.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.01 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. This antibody is suitable for use until the expiration date when stored at 2-8°C. Do not use product after the expiration date printed on vial. If reagents are stored under conditions other than those specified here, they must be verified by the user. Diluted reagents should be used promptly. Unused portions of antibody preparation should be discarded after one day. The presence of precipitate or an unusual odor indicates that the antibody is deteriorating and should not be used.

Target Details for EBV LMP1

Target: EBV LMP1 (Epstein-Barr Virus Latent Membrane Protein 1 (EBV LMP1))

Alternative Name: EBV LMP-1 (EBV LMP1 Products)

Target Type: Viral Protein

Background: Epstein-Barr Virus, EBV, Latent Membrane Protein 1, Human herpesvirus 4, HHV-4,Latent membrane protein 1 acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. It functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. It interacts with host UBE2I and subsequently affects the sumoylation state of several cellular proteins. For example, LMP1 induces the sumoylation of host IRF7 thereby limiting its transcriptional activity and modulating the activation of innate immune responses.