KIDINS220 antibody (pSer918)

Catalog No. ABIN722095

Product Details anti-KIDINS220 Antibody

Target: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Binding Specificity: pSer918

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIDINS220 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Pig,Chicken,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Kidins220 around the phosphorylation site of Ser918

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for KIDINS220

Target: KIDINS220 (Kinase D-Interacting Substrate, 220kDa (KIDINS220))

Alternative Name: Kidins220 (KIDINS220 Products)

Synonyms: ARMS antibody, fj35h03 antibody, kidins220 antibody, zgc:63531 antibody, dZ119J18.2 antibody, wu:fj35h03 antibody, 3110039L19Rik antibody, AI194387 antibody, AI316525 antibody, C330002I19Rik antibody, mKIAA1250 antibody, kinase D interacting substrate 220 antibody, kinase D-interacting substrate 220 antibody, kinase D-interacting substrate 220b antibody, kinase D-interacting substrate 220kDa antibody, KIDINS220 antibody, Kidins220 antibody, kidins220b antibody

Background:

Synonyms: Kidins220 phospho S918, Ankyrin repeat-rich membrane-spanning protein, arms, KDIS_HUMAN, Kidins220, Kinase D interacting substance of 220 kDa, Kinase D-interacting substrate of 220 kDa, rgd 619949.

Background: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

Gene ID: 57498