CD207 antibody (PE)

Catalog No. ABIN7540425

Product Details anti-CD207 Antibody (PE)

Target: CD207 (CD207 Molecule, Langerin (CD207))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD207 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Purpose: Anti-Hu CD207 PE

Specificity: The mouse monoclonal antibody 2G3 recognizes an extracellular/luminal epitope of CD207, a transmembrane protein selectively expressed by Langerhans cells and by some other dendritic cell subsets. This antibody clone can target vaccine-peptides to dendritic cells.

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Fusion protein of human CD207 extracellular part and IgG Fc fragment

Clone: 2G3

Isotype: IgG1 lambda

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. Extracellular and intracellular staining.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for CD207

Target: CD207 (CD207 Molecule, Langerin (CD207))

Alternative Name: CD207 (CD207 Products)

Background:

NCBI Full Gene Name: CD207 Molecule

Description: CD207 is a 40 kDa type II transmembrane glycoprotein of the C-type lectin family. It binds to mannose-bearing glycoproteins and glycolipids of microbial and viral antigens, including HIV gp120. CD207 is expressed only in Langerhans cells, which are immature dendritic cells of the epidermis and mucosa, and its expression decreases during Langerhans cells maturation. Upon antigen binding CD207 localizes to the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed membranes, which leads to a nonclassical antigen-processing pathway.

Other names: CLEC4K, langerin

Gene name: CD207

Gene ID: 50489

UniProt: Q9UJ71