SH2B2 antibody (AA 497-676)

Catalog No. ABIN7539759

Product Details anti-SH2B2 Antibody

Target: SH2B2 (SH2B Adaptor Protein 2 (SH2B2))

Binding Specificity: AA 497-676

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SH2B2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purpose: SH2B2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human SH2B2 (AA: 497-676) expressed in E. Coli.

Clone: 5E11G7

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for SH2B2

Target: SH2B2 (SH2B Adaptor Protein 2 (SH2B2))

Alternative Name: SH2B2 (SH2B2 Products)

Synonyms: APS antibody, Aps antibody, SH2B adaptor protein 2 antibody, SH2B2 antibody, Sh2b2 antibody

Background:

Description: The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway.

Aliases: APS

Molecular Weight: 67.7 kDa

Gene ID: 10603

UniProt: O14492

Pathways: Carbohydrate Homeostasis, Brown Fat Cell Differentiation