DCLK2 antibody (AA 652-766)

Catalog No. ABIN7539736

Product Details anti-DCLK2 Antibody

Target: DCLK2 (Doublecortin-Like Kinase 2 (DCLK2))

Binding Specificity: AA 652-766

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DCLK2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purpose: DCLK2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human DCLK2 (AA: 652-766) expressed in mammalian.

Clone: 3H1G4

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for DCLK2

Target: DCLK2 (Doublecortin-Like Kinase 2 (DCLK2))

Alternative Name: DCLK2 (DCLK2 Products)

Background:

Description: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.

Aliases: CL2, DCK2, CLIK2, DCDC3, CLICK2, DCDC3B, DCAMKL2, CLICK-II

Molecular Weight: 83.6 kDa

Gene ID: 166614

UniProt: Q8N568