FcRn antibody

Catalog No. ABIN7539617

Product Details anti-FcRn Antibody

Key Features:

• High-quality FcRn antibody (Clone ADM31) for the detection of FcRn.
• Highly specific for human FcRn, blocks the binding of human serum albumin.
• contains Glycerol for better storage.

Target: FcRn (IgG receptor FcRn (FcRn))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FcRn antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Cell-ELISA (cELISA), Functional Studies (Func)

Characteristics: based on recognition of the complete native protein expressed on transfected mammalian cells

Purification: Purified, Protein G

Immunogen: hFcRn

Clone: ADM31

Isotype: IgG2b lambda

Product Specific Information:

What can the FcRn antibody ABIN7539617 / ADM31 antibody be used for? This monoclonal mouse anti-FcRn antibody is unconjugated and is suitable for the detection of FcRn (Fc receptor) in human samples. The FcRn antibody is validated for Cell ELISA, ELISA, FACS and IF.

What validation data is available for this FcRn antibody / ADM31 antibody? 6 images for FACS and other applications are available. The product is cited in 15 PubMed publications. User our high quality product to reliably detect Fc receptor.

The MHC class I-like Fc receptor (FcRn) functions as an intracellular trafficking receptor, uniquely accountable for prolonging the serum half-life of IgG subclass antibodies and facilitating their passage across cellular barriers. Through these actions, FcRn significantly impacts various aspects of antibody biology and pathobiology. Its crucial role in regulating IgG pharmacokinetics has been exploited in the development of therapeutic antibodies and related biological treatments. Additionally, FcRn is involved in the transport of serum albumin, contributing to the improved pharmacokinetic characteristics of albumin-conjugated therapies. However, a lack of dependable serological tools targeting human FcRn has limited the comprehension of its functions and potential therapeutic uses.

Limited uses of our FcRn antibody ABIN7539617 / ADM31

Application Details

Application Notes:

• Flow cytometry: 1.2 μg/10^6 cells
• ELISA: 1:200 - 1:400
• CELISA: 1:200 - 1:400

For each application a titration should be performed to determine the optimal concentration.

Restrictions: For Research Use only

Handling

Buffer: PBS pH 7.2 with 50% glycerol

Handling Advice: avoid repeated freezing and thawing

Storage: 4 °C

Target Details for FcRn

Target: FcRn (IgG receptor FcRn (FcRn))

Alternative Name: Fc Receptor (FcRn) FcRn (FcRn Products)

Synonyms: FCRN antibody, alpha-chain antibody, FcRn antibody, Fc fragment of IgG receptor and transporter antibody, Fc receptor, IgG, alpha chain transporter antibody, FCGRT antibody, Fcgrt antibody

Background: The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics.
Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT

UniProt: P55899

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process