GLMN antibody (AA 151-250) (Biotin)

Catalog No. ABIN721947

Product Details anti-GLMN Antibody (Biotin)

Target: GLMN (Glomulin, FKBP Associated Protein (GLMN))

Binding Specificity: AA 151-250

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLMN antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FK506 binding protein associated protein

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for GLMN

Target: GLMN (Glomulin, FKBP Associated Protein (GLMN))

Alternative Name: FK506 binding protein associated protein (GLMN Products)

Synonyms: FAP antibody, FAP48 antibody, FAP68 antibody, FKBPAP antibody, GLML antibody, GVM antibody, VMGLOM antibody, 9330160J16Rik antibody, AW227515 antibody, Fap48 antibody, Fap68 antibody, MGC69174 antibody, GLMN antibody, zgc:194957 antibody, glmnl antibody, zgc:101567 antibody, glomulin, FKBP associated protein antibody, glomulin, FKBP associated protein L homeolog antibody, glomulin, FKBP associated protein b antibody, glomulin, FKBP associated protein a antibody, GLMN antibody, Glmn antibody, glmn.L antibody, glmn antibody, glmnb antibody, glmna antibody

Background:

Synonyms: FAP, GVM, GLML, FAP48, FAP68, FKBPAP, VMGLOM, Glomulin, FK506-binding protein-associated protein, FKBP-associated protein, GLMN, GLMN_HUMAN

Background: Isoform 1: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes.). Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34. Inhibits RBX1-mediated neddylation of CUL1. Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity). Essential for normal development of the vasculature. Contributes to the regulation of RPS6KB1 phosphorylation

Gene ID: 11146

UniProt: Q92990

Pathways: Tube Formation