S100A1 antibody

Catalog No. ABIN7538098

Product Details anti-S100A1 Antibody

Target: S100A1 (S100 Calcium Binding Protein A1 (S100A1))

Reactivity: Human, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This S100A1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Rabbit polyclonal antibodies to Bovine S100

Specificity: Specific to all isotypes (alpha:alpha, alpha:beta and beta:beta)

Cross-Reactivity (Details): May cross-react with other species

Purification: Protein A affinity column

Immunogen: Native source protein

Isotype: IgG, IgM

Application Details

Application Notes: Western blot: 0.1-1.0 μg/mL

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Glycine pH 7.2

Storage: 4 °C,-80 °C

Storage Comment: Short term up to 1 month at 2-8°C, long term can be held for up to five years at -70°C

Target Details for S100A1

Target: S100A1 (S100 Calcium Binding Protein A1 (S100A1))

Alternative Name: S100 (S100A1 Products)

Background: Small calcium binding protein that plays important roles in several biological processes such as Ca2+ homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca2+ levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca2+ cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca2+-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca2+ dissociation and myofilament mechanics in order to improve relaxation during diastole

Molecular Weight: 10668 Da (beta), 10518 Da (alpha)

Pathways: Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades, S100 Proteins