CD51/CD61 antibody (PE)

Catalog No. ABIN7506149

Product Details anti-CD51/CD61 Antibody (PE)

Target: CD51/CD61 (ITGAV/ITGB3) (Integrin AlphaV, Integrin Beta3 (ITGAV/ITGB3))

Reactivity: Human, Chicken

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD51/CD61 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Purpose: Anti-Hu CD51/CD61 PE

Specificity: The mouse monoclonal antibody 23C6 recognizes an extracellular epitope on CD51/CD61 complex, that is expressed mainly on human osteoclasts, but also e.g. on placenta, or melanoma cell lines. The epitope is native and sensitive to fixation. In chicken this antibody can be used to selectively identify the thrombocytes.

No Cross-Reactivity: Cow, Pig, Rabbit

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: A cell suspension containing osteoclasts from osteoclastomas

Clone: 23C6

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Restrictions: For Research Use only

Handling

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Target Details for CD51/CD61

Target: CD51/CD61 (ITGAV/ITGB3) (Integrin AlphaV, Integrin Beta3 (ITGAV/ITGB3))

Alternative Name: CD51/CD61 (ITGAV/ITGB3 Products)

Synonyms: CD51 antibody, MSK8 antibody, VNRA antibody, VTNR antibody, integrin subunit alpha V antibody, ITGAV antibody

Background: CD51/CD61 (integrin alpha5beta3), also known as osteoclast functional antigen, serves as a vitronectin receptor, and binds also to fibronectin, fibrinogen, thrombospondin, osteopontin, collagen, and von Willebrand factor. Expression of this antigen increases with melanoma progression. In healthy individuals CD51/CD61 is expressed mainly on osteoclasts, placenta, and endothelial cells, at lower levels on platelets and macrophages.,VNRA, MSK8, ITGB3, ITGAV, Integrin alpha5beta3, OFA, VR