TIAL1 antibody

Catalog No. ABIN7506023

Product Details anti-TIAL1 Antibody

Target: TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))

Reactivity: Human, Mouse, Non-Human Primate

Host: Mouse

Clonality: Monoclonal

Conjugate: This TIAL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purpose: Anti-TIAR Purified

Specificity: The mouse monoclonal antibody 6E3 recognizes TIAR, an ubiquitously expressed approximately 42 kDa intracellular RNA-binding protein.

Purification: Purified by protein-A affinity chromatography.

Immunogen: GST-tagged recombinant human TIAR

Clone: 6E3

Isotype: IgG2a kappa

Application Details

Application Notes: Flow cytometry: Intracellular staining, recommended dilution: 5 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for TIAL1

Target: TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))

Alternative Name: TIAR (TIAL1 Products)

Synonyms: TCBP antibody, TIAR antibody, 5330433G13Rik antibody, AL033329 antibody, mTIAR antibody, zgc:66130 antibody, tcbp antibody, tiar antibody, TIA1 cytotoxic granule associated RNA binding protein like 1 antibody, Tia1 cytotoxic granule-associated RNA binding protein-like 1 antibody, TIA1 cytotoxic granule-associated RNA binding protein-like 1 antibody, TIAL1 antibody, Tial1 antibody, tial1 antibody

Background: TIA1 cytotoxic granule associated RNA binding prot,TIAR is an ubiquitously expressed RNA-binding protein, which regulates translational control, splicing, and other activities, including apoptosis. TIAR attenuates CDK1 activity, and is essential for the G2/M checkpoint. It accumulates in nuclear foci in late G2 phase and prophase in cells under replication stress. In steady state TIAR shuttles between the cytoplasm and the nucleus, probably as a part of nucleocytoplasmic transport of mRNA, but under stress conditions it accumulates mRNA molecules in granules and prevents their translation. Nucleolytic activity of TIAR against attacked target cells of cytotoxic lymphocytes has also been reported. Similarly, e.g. in permeabilized thymocytes TIAR triggers DNA fragmentation.,TCBP, TIAL1

Gene ID: 7073

UniProt: Q01085