PLEC antibody

Catalog No. ABIN7489970

Product Details anti-PLEC Antibody

Target: PLEC (Plectin (PLEC))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PLEC antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Affinity purification

Immunogen: Recombinant protein of human Plectin .

Clone: ARC53240

Isotype: IgG

Application Details

Application Notes: IHC-P 1:100 – 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles.

Storage: -20 °C

Target Details for PLEC

Target: PLEC (Plectin (PLEC))

Alternative Name: Plectin (PLEC Products)

Synonyms: EBS1 antibody, EBSO antibody, HD1 antibody, LGMD2Q antibody, PCN antibody, PLEC1 antibody, PLEC1b antibody, PLTN antibody, AA591047 antibody, AU042537 antibody, Plec1 antibody, Pcn antibody, Pltn antibody, IFAP300 antibody, Plectin-1 antibody, plectin antibody, plectin L homeolog antibody, LOC100481602 antibody, plec.L antibody, PLEC antibody, Plec antibody, LOC786966 antibody

Background: Synonyms: HD1; PCN; EBS1; EBSO; PLTN; EBS5A; EBS5B; EBS5C; EBS5D; EBSMD; EBSND; EBSOG; EBSPA; PLEC1; LGMD2Q; PLEC1b; LGMDR17; Plectin
Background: Plectin is a large, widely expressed protein that crosslinks the intermediate filament and actin cytoskeleton, mechanically stabilizing cells and tissues. Plectin also plays a role in the regulation of actin dynamics and acts as a scaffold for signaling molecules. Plectin is important in the stabilization of hemidesmosomes, crosslinking them to the intermediate filament network. Research studies have shown that mutations in plectin and other genes coding for hemidesmosomal proteins can cause epidermolysis bullosa, a condition manifested by fragile skin and frequent blistering . Plectin modulates signals to PKC through binding and sequestration of RACK1, the receptor for activated C kinase 1 . Plectin is also involved in the regulation of cytokeratin architecture and cell stress response , signaling through the chemokine receptor CXCR4 and regulation of AMP-activated protein kinase (AMPK) activity and signaling in mouse myotubes .

Gene ID: 5339

UniProt: Q15149