Recombinant TNF alpha (Humicade Biosimilar) antibody

Catalog No. ABIN7487761

Product Details

Target: TNF alpha (Humicade Biosimilar)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Chimeric

Conjugate: Un-conjugated

Application: ELISA

Purpose: Anti-TNF alpha [CDP 571 (Humicade)], Mouse IgG1, kappa

Specificity: The antibody binds to human TNF-alpha with a Kd of 0.087 nM.

Characteristics:

Original Species of Ab: Human

Original Format of Ab: IgG4

Purification: Protein A affinity purified

Immunogen: Human TNF-alpha

Clone: CDP 571

Isotype: IgG1 kappa

Application Details

Application Notes: The antibody binds specifically to TNF-alpha, a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB.

Comment:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details

Target: TNF alpha (Humicade Biosimilar)

Target Type: Biosimilar

Background: TNFA, Tumour necrosis factor superfamily member 2, TNFSF2

UniProt: P01375